Letter to the Editor: Mesenchymal stromal cell-derived extracellular vesicles as a promising therapeutic candidate for attenuating cellular senescence

doi:10.4252/wjsc.114501

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Stem Cells. Jun 26, 2026; 18(6): 114501
Published online Jun 26, 2026. doi: 10.4252/wjsc.114501

Letter to the Editor: Mesenchymal stromal cell-derived extracellular vesicles as a promising therapeutic candidate for attenuating cellular senescence

Wei Zhang, Jing-Long Luo, Li Xiao, Jian-Guang Zhang

Wei Zhang, Jing-Long Luo, Guangdong Eco-Engineering Polytechnic, Guangzhou 510520, Guangdong Province, China

Li Xiao, Guangdong Provincial Biotechnology Research Institute (Guangdong Provincial Laboratory Animals Monitoring Center), Guangzhou 510663, Guangdong Province, China

Jian-Guang Zhang, Xiamen Institute for Food and Drug Quality Control, Xiamen 361012, Fujian Province, China

Co-corresponding authors: Li Xiao and Jian-Guang Zhang.

Author contributions: Xiao L and Zhang JG contributed equally to this manuscript and are co-corresponding authors. Xiao L and Zhang JG contributed to the writing, reviewing and editing; Zhang W, Luo JL, Xiao L, and Zhang JG contributed to the conceptualization of this manuscript; Zhang W and Luo JL participated in the writing of the original draft. All authors have read and approved the final version of the manuscript.

AI contribution statement: We fully adhere to the journal’s policies on AI usage. DeepSeek’s role was strictly limited to language refinement (e.g., structural coherence, grammar) and did not extend to research design, analysis, or intellectual contributions. The manuscript complies with all ethical and publication standards.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Jian-Guang Zhang, PhD, Xiamen Institute for Food and Drug Quality Control, No. 33 Dongdu Haishan Road, Huli District, Xiamen 361012, Fujian Province, China. jianguangcn@163.com

Received: September 22, 2025
Revised: November 6, 2025
Accepted: January 4, 2026
Published online: June 26, 2026
Processing time: 276 Days and 21.3 Hours

Core Tip

Core Tip: This study by Yang et al provided evidence that clinically produced mesenchymal stromal cell-derived extracellular vesicles effectively counteract cellular senescence. They reduce senescence markers and restore collagen expression in aged human dermal fibroblasts, while mitigating oxidative stress and aging-related gene expression in a D-gal-induced aging mouse model. These results highlight the potential of mesenchymal stromal cell-derived extracellular vesicles as a ready-to-use biologic strategy against aging and aging-associated tissue damage, paving the way for their further clinical development.