©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Apr 26, 2025; 17(4): 102923
Published online Apr 26, 2025. doi: 10.4252/wjsc.v17.i4.102923
Published online Apr 26, 2025. doi: 10.4252/wjsc.v17.i4.102923
Mechanisms and challenges of mesenchymal stem cells in the treatment of knee osteoarthritis
Jing-Shun Lu, Wen-Jing Cheng, Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Wuhu 241000, Anhui Province, China
Chen-Yu Song, Kai-Yang Wang, Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
Author contributions: Lu JS wrote and edited the manuscript; Song CY and Cheng WJ contributed to review and editing; Wang KY conceived, reviewed, and revised the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Kai-Yang Wang, MD, Assistant Professor, Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, No. 600 Yishan Road, Shanghai 200233, China. ortho_wang@163.com
Received: November 4, 2024
Revised: February 22, 2025
Accepted: March 21, 2025
Published online: April 26, 2025
Processing time: 172 Days and 13 Hours
Revised: February 22, 2025
Accepted: March 21, 2025
Published online: April 26, 2025
Processing time: 172 Days and 13 Hours
Core Tip
Core Tip: Mesenchymal stem cells (MSCs) exhibit remarkable efficacy in the field of regenerative medicine and are considered to be the key cells for the repair and regene