©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Apr 26, 2025; 17(4): 102482
Published online Apr 26, 2025. doi: 10.4252/wjsc.v17.i4.102482
Published online Apr 26, 2025. doi: 10.4252/wjsc.v17.i4.102482
Hypoxic endometrial epithelial cell-derived microRNAs effectively regulate the regenerative properties of mesenchymal stromal cells
Panagiotis Mallis, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Athens 11527, Attikí, Greece
Author contributions: Mallis P wrote and revised the manuscript.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Corresponding author: Panagiotis Mallis, PhD, Postdoctoral Fellow, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 4 Soranou Ephessiou Street, Athens 11527, Attikí, Greece. pmallis@bioacademy.gr
Received: October 21, 2024
Revised: February 6, 2025
Accepted: March 5, 2025
Published online: April 26, 2025
Processing time: 186 Days and 8.9 Hours
Revised: February 6, 2025
Accepted: March 5, 2025
Published online: April 26, 2025
Processing time: 186 Days and 8.9 Hours
Core Tip
Core Tip: Endometrial tissue damage is the primary reason for unsuccessful embryo implantation. Hypoxic damaged endometrial epithelial cells can secrete miRNAs through exosomes, which can efficiently regulate endometrial microenvironment homeostasis. Specifically, miR-21-5p and miR-214-5p can regulate the migration, wound healing and differentiation of umbilical cord-derived mesenchymal stromal cells. Therefore, the latter favors endometrial tissue regeneration. By understanding the primary endometrial defect, alternative therapeutic protocols such as advanced cellular therapies may be used to restore women’s fertility.