Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Nov 26, 2025; 17(11): 110381
Published online Nov 26, 2025. doi: 10.4252/wjsc.v17.i11.110381
Published online Nov 26, 2025. doi: 10.4252/wjsc.v17.i11.110381
Cancer cell-dependent increase in senescence-like populations following exosome treatment from bone marrow and induced pluripotent stem cell-derived mesenchymal stem cells
Nidaa A Ababneh, Sura Nashwan, Mohammad A Ismail, Abdalla Awidi, Cell Therapy Center, University of Jordan, Amman 11942, Jordan
Razan AlDiqs, Department of Allied Sciences, Faculty of Arts and Sciences, Al-Ahliyya Amman University, Amman 19111, Jordan
Mohammad A Ismail, South Australian ImmunoGENomics Cancer Institute, Adelaide Medical School, University of Adelaide, Adelaide 5005, Australia
Ahmed A Abdulelah, Lina AlQirem, School of Medicine, University of Jordan, Amman 11942, Jordan
Ahmed A Abdulelah, Royal Papworth Hospital NHS Foundation Trust, Royal Papworth Hospital, Cambridge CB2 0AY, United Kingdom
Anas H A Abu-Humaidan, Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, University of Jordan, Amman 11942, Jordan
Lina AlQirem, University of Arkansas for Medical Sciences, Arkansas City, KS 72205, United States
Khairallah Al-Abdallat, Bone Marrow Transplantation Unit, Jordan University Hospital, Amman 11942, Jordan
Khairallah Al-Abdallat, Abdalla Awidi, Hemostasis and Thrombosis Laboratory, School of Medicine, University of Jordan, Amman 11942, Jordan
Talal Al-Qaisi, Department of Biomedical Sciences, College of Health Sciences, Abu Dhabi University, Abu Dhabi 59911, United Arab Emirates
Tareq Saleh, Department of Pharmacology & Therapeutics, College of Medicine & Health Sciences Manama, Arabian Gulf University, Manama 329, Bahrain
Tareq Saleh, Department of Pharmacology and Public Health, Faculty of Medicine, The Hashemite University, Zarqa 13133, Jordan
Abdalla Awidi, Department of Hematology and Oncology, Jordan University Hospital, Amman 11942, Jordan
Author contributions: Ababneh NA and Awidi A conceptualized the study and supervised the study; Ababneh NA, Nashwan S, and Ismail MA carried out the experiments; Nashwan S and AlDiqs R wrote the initial draft of the manuscript; Ababneh NA, AlDiqs R, Abdulelah AA, Abu-Humaidan AHA, AlQirem L, Al-Abdallat K, Al-Qaisi T, and Saleh T revised and edited the manuscript; Ababneh NA, AlDiqs R, and Saleh T performed the formal analysis and results interpretation; All authors read and approved the final version of the publication.
Institutional review board statement: This study fully adhered to ethical standards and guidelines. It received approval from the Institutional Review Board, No. IRB-CTC/2-2021/06 at the Cell Therapy Center, University of Jordan in accordance with the Declaration of Helsinki.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nidaa A Ababneh, Associate Professor, Cell Therapy Center, University of Jordan, Queen Rania Street, Amman 11942, Jordan. n.ababneh@ju.edu.jo
Received: June 7, 2025
Revised: July 29, 2025
Accepted: October 9, 2025
Published online: November 26, 2025
Processing time: 173 Days and 5.1 Hours
Revised: July 29, 2025
Accepted: October 9, 2025
Published online: November 26, 2025
Processing time: 173 Days and 5.1 Hours
Core Tip
Core Tip: This study explored the effects of exosomes (Exos) obtained from bone marrow mesenchymal stem cells (MSCs) and MSCs derived from induced pluripotent stem cells on pancreatic and triple-negative breast cancer cells. Exos obtained from MSCs derived from induced pluripotent stem cells exhibited a stronger and sustained antiproliferative effect by inducing a senescence-like state without apoptosis. In contrast, bone marrow MSC-derived Exos showed variable effects depending on cancer type. These findings highlight the importance of Exos source in determining therapeutic outcomes and suggest senescence induction as a key response to Exos exposure.