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World J Stem Cells. Aug 26, 2024; 16(8): 799-810
Published online Aug 26, 2024. doi: 10.4252/wjsc.v16.i8.799
Bone marrow mesenchymal stem cells in treatment of peripheral nerve injury
Xiong-Fei Zou, Bao-Zhong Zhang, Wen-Wei Qian, Florence Mei Cheng
Xiong-Fei Zou, Bao-Zhong Zhang, Wen-Wei Qian, Department of Orthopedic Surgery, Peking Union Medical College Hospital, Beijing 100730, China
Florence Mei Cheng, College of Nursing, The Ohio State University, Ohio, OH 43210, United States
Co-corresponding authors: Bao-Zhong Zhang and Wen-Wei Qian.
Author contributions: Zou XF, Zhang BZ, and Qian WW proposed the research topic and designed the research method; Zou XF organized and analyzed the literature and wrote and revised the manuscript; Zhang BZ and Qian WW provided critical revisions for the article; Cheng FM polished the language of the article. All authors have read and approved the final manuscript. Zhang BZ and Qian WW contributed equally to this paper and should be considered as co-corresponding authors.
Supported by CAMS Innovation Fund for Medical Sciences, No. 2022-I2M-C&T-B-034.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bao-Zhong Zhang, MD, Chief Physician, Professor, Department of Orthopedic Surgery, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Wangfujing, Beijing 100730, China. zhangbzh@pumch.cn
Received: March 7, 2024
Revised: May 20, 2024
Accepted: August 5, 2024
Published online: August 26, 2024
Processing time: 171 Days and 23.6 Hours
Core Tip

Core Tip: Bone marrow mesenchymal stem cells (BMSCs) have become ideal seed cells for the treatment of peripheral nerve injury (PNI) due to their strong differentiation potential and the possibility of autologous transplantation. In this review, we introduce the biological characteristics of BMSCs related to PNI, outline the current mechanisms by which BMSCs promote the regeneration and repair of PNI, and summarize the various application methods of BMSCs in PNI, confirming the potential of BMSCs in the treatment of PNI and providing great support for the development of new treatment strategies for nerve regeneration and repair in PNI.