Priming mesenchymal stem cells to develop “super stem cells”

doi:10.4252/wjsc.v16.i6.623

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Jun 26, 2024 (publication date) through Mar 2, 2026

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jun 26, 2024; 16(6): 623-640
Published online Jun 26, 2024. doi: 10.4252/wjsc.v16.i6.623

Priming mesenchymal stem cells to develop “super stem cells”

Khawaja Husnain Haider

Khawaja Husnain Haider, Department of Basic Sciences, Sulaiman AlRajhi University, AlQaseem 52736, Saudi Arabia

Author contributions: Haider KH conceived and wrote, read, revised, and approved the final manuscript.

Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.

Corresponding author: Khawaja Husnain Haider, BPharm, BSc, PhD, Chairman, Full Professor, Department of Basic Sciences, Sulaiman AlRajhi University, AlMadina Road, AlQaseem 52736, Saudi Arabia. kh.haider@sr.edu.sa

Received: April 2, 2024
Revised: May 4, 2024
Accepted: May 20, 2024
Published online: June 26, 2024
Processing time: 83 Days and 11.9 Hours

Core Tip

Core Tip: Stem cell pre-treatment is a promising approach for accentuating their stemness and reparability and improving their resistance to apoptosis in the harsh microenvironment of the injured tissue. The current stem cell pre-treatment protocols allow for enhancing their therapeutic efficacy to surmount the limitations of mesenchymal stem cells (MSCs), i.e., mobility, survival, engraftment, and paracrine activity. Besides a novel sub-cellular preconditioning strategy, the combinative preconditioning approach exposing the cells to a proinflammatory milieu under hypoxia improves MSCs’ immunoregulatory potential. Refining a combinatorial pre-treatment protocol using a well-defined mechanistic understanding may allow the exploitation of the full benefits of the pre-treated “super MSCs” for enhanced stemness, functionality, and reparability, including immunosuppressive and immunomodulatory properties.