Mushtaq M, Zineldeen DH, Mateen MA, Haider KH. Mesenchymal stem cells’ “garbage bags” at work: Treating radial nerve injury with mesenchymal stem cell-derived exosomes. World J Stem Cells 2024; 16(5): 467-478 [PMID: 38817330 DOI: 10.4252/wjsc.v16.i5.467]
Corresponding Author of This Article
Khawaja Husnain Haider, BSc, BPharm, MPharm, PhD, Chairman, Full Professor, Department of Basic Sciences, Sulaiman AlRajhi University, AlMadina Road, Albukairiyah 52736, AlQaseem, Saudi Arabia. kh.haider@sr.edu.sa
Research Domain of This Article
Cell & Tissue Engineering
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. May 26, 2024; 16(5): 467-478 Published online May 26, 2024. doi: 10.4252/wjsc.v16.i5.467
Mesenchymal stem cells’ “garbage bags” at work: Treating radial nerve injury with mesenchymal stem cell-derived exosomes
Mazhar Mushtaq, Doaa Hussein Zineldeen, Muhammad Abdul Mateen, Khawaja Husnain Haider
Mazhar Mushtaq, Doaa Hussein Zineldeen, Muhammad Abdul Mateen, Khawaja Husnain Haider, Department of Basic Sciences, Sulaiman AlRajhi University, Albukairiyah 52736, AlQaseem, Saudi Arabia
Doaa Hussein Zineldeen, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Tanta University, Tanta 6632110, Egypt
Author contributions: Zineldeen DH contributed to writing and generating the visual abstract of this manuscript; Mushtaq M and Mateen MA were involved in writing up and revising this article; Mateen MA contributed to the figures; and Haider KH participated in writing, finalizing, and submitting the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Khawaja Husnain Haider, BSc, BPharm, MPharm, PhD, Chairman, Full Professor, Department of Basic Sciences, Sulaiman AlRajhi University, AlMadina Road, Albukairiyah 52736, AlQaseem, Saudi Arabia. kh.haider@sr.edu.sa
Received: February 20, 2024 Revised: April 3, 2024 Accepted: April 25, 2024 Published online: May 26, 2024 Processing time: 93 Days and 21.6 Hours
Core Tip
Core Tip: The extracellular vesicles constituting the insoluble component of the secretome were once considered cell’s garbage bags. They have become a hot area of research since realizing their significance as an essential means of intracellular communication. They have shown promise for therapeutic applications for repairing and regenerating the damaged tissues via delivering their payload to the resident reparative cells and supporting them in the intrinsic repair process. Although stem cell-derived exosomes have been extensively studied for peripheral nerve injury repair in experimental animal models, their use for radial nerve injury repair in a patient, as the pilot study by Civelek et al, is expected to pave the way for assessment in future clinical trials.
