Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. May 26, 2024; 16(5): 462-466
Published online May 26, 2024. doi: 10.4252/wjsc.v16.i5.462
Single-cell sequencing technology in diabetic wound healing: New insights into the progenitors-based repair strategies
Zhen Xiang, Rui-Peng Cai, Yang Xiao, Yong-Can Huang
Zhen Xiang, Rui-Peng Cai, Yong-Can Huang, Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies, Department of Spine Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Yang Xiao, Department of Breast and Thyroid Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Co-first authors: Zhen Xiang and Rui-Peng Cai.
Author contributions: Xiang Z and Cai RP contributed equally to this editorial, they drafted and revised the manuscript; Xiao Y read and revised the manuscript; Huang YC conceived the study and approved the final manuscript; and all authors approved the final version of the paper.
Supported by Shenzhen Science and Technology Program, No. GJHZ20210705142543019; and Guangdong Basic and Applied Basic Research Foundation, No. 2023A1515220074.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong-Can Huang, PhD, Associate Professor, Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies, Department of Spine Surgery, Peking University Shenzhen Hospital, Lianhua Road, Shenzhen 518036, Guangdong Province, China. y.c.huang@connect.hku.hk
Received: December 26, 2023
Revised: March 8, 2024
Accepted: March 25, 2024
Published online: May 26, 2024
Processing time: 150 Days and 1.7 Hours
Core Tip

Core Tip: Understanding the mechanism of diabetic wound healing is crucial for the development of novel therapeutic strategies. In this editorial, we focus on advances in the biological behaviour of various healing-related cells and the alteration of signalling pathways in the process of diabetic wound healing. Single-cell RNA sequencing (scRNAseq) has emerged as a powerful tool to explore cellular heterogeneity, reveal new cell subpopulations and predict developmental trajectories. Summarising the current results of scRNAseq in diabetic wounds has provided new insights into progenitor-based repair strategies and possible therapeutic targets.