Preliminary study on the preparation of lyophilized acellular nerve scaffold complexes from rabbit sciatic nerves with human umbilical cord mesenchymal stem cells
Chuang Qian, Shang-Yu Guo, Zheng Xu, Zhi-Qiang Zhang, Hao-Dong Li, Hao Li, Xiong-Sheng Chen
Chuang Qian, Shang-Yu Guo, Zhi-Qiang Zhang, Hao-Dong Li, Xiong-Sheng Chen, Department of Orthopedics, Children’s Hospital of Fudan University & National Children’s Medical Center, Shanghai 201102, China
Zheng Xu, Spine Center, Department of Orthopaedics, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China
Hao Li, Department of Neurosurgery, Children’s Hospital of Fudan University & National Children’s Medical Center, Shanghai 201102, China
Co-first authors: Chuang Qian and Shang-Yu Guo.
Co-corresponding authors: Hao Li and Xiong-Sheng Chen.
Author contributions: Qian C and Guo SY contributed equally to this work and are co-first authors. Li H and Chen XS contributed equally to this work and are co-corresponding authors. Qian C and Guo SY carried out the experiments, participated in the data collection, and drafted the manuscript; Qian C, Guo SY, Xu Z, Zhang ZQ, Li HD, Li H and Chen XS performed the statistical analysis and participated in the study design; Qian C and Guo SY helped draft the manuscript; and all authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of Children’s Hospital of Fudan University &National Children’s Medical Center.
Institutional animal care and use committee statement: The Institutional Animal Care, Ethics, and Use Committees of Children’s Hospital of Fudan University approved all animal experiments, No. 2024-EKYY-151.
Conflict-of-interest statement: The authors declare no competing interests.
Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author upon reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Hao Li, PhD, Doctor, Department of Neurosurgery, Children’s Hospital of Fudan University & National Children’s Medical Center, No. 399 Wanyuan Road, Minghang District, Shanghai 201102, China.
lihao7272@163.com
Received: August 20, 2024
Revised: October 9, 2024
Accepted: November 29, 2024
Published online: December 26, 2024
Processing time: 114 Days and 19.1 Hours
