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World J Stem Cells. Dec 26, 2024; 16(12): 1002-1011
Published online Dec 26, 2024. doi: 10.4252/wjsc.v16.i12.1002
Dual role of extracellular vesicles in neurodegenerative diseases
Arianna Scuteri, Elisabetta Donzelli
Arianna Scuteri, Elisabetta Donzelli, Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza 20900, Italy
Co-first authors: Arianna Scuteri and Elisabetta Donzelli.
Author contributions: Scuteri A conceptualized the work and wrote the original draft; Scuteri A and Donzelli E wrote, edited and revised the paper. All the authors have equally contributed to the paper, read and agreed to the published version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Arianna Scuteri, Associate Professor, PhD, Professor, Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, Monza 20900, Italy. arianna.scuteri@unimib.it
Received: August 30, 2024
Revised: October 17, 2024
Accepted: November 22, 2024
Published online: December 26, 2024
Processing time: 104 Days and 19.7 Hours
Core Tip

Core Tip: An increasing number of studies in the literature have focused on the role of extracellular vesicles (EVs) in the progression of several diseases, particularly neurodegenerative diseases, in which EVs are presumed to transfer pathological molecules to normal cells. Nevertheless, many therapeutic strategies focus on the use of EVs to deliver prosurvival factors; however, apparent discrepancies are noted. In this review, we focused on neurodegenerative diseases to shed light on the dual role that EVs play and explored, in particular, the potential therapeutic role of stem cell-derived EVs.