Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Nov 26, 2024; 16(11): 985-989
Published online Nov 26, 2024. doi: 10.4252/wjsc.v16.i11.985
Melatonin-based priming of stem cells to alleviate oxidative stress
Khawaja Husnain Haider
Khawaja Husnain Haider, Department of Basic Sciences, Sulaiman Al Rajhi University, Al Bukairiyah 51941, AlQaseem, Saudi Arabia
Author contributions: Haider KH conceptualized, wrote, reviewed, and edited the manuscript, and approved the publication of the final manuscript.
Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Khawaja Husnain Haider, PhD, Professor, Department of Basic Sciences, Sulaiman Al Rajhi University, PO Box 777, Al Bukairiyah 51941, AlQaseem, Saudi Arabia. kh.haider@sr.edu.sa
Received: September 17, 2024
Revised: September 28, 2024
Accepted: October 18, 2024
Published online: November 26, 2024
Processing time: 70 Days and 0.9 Hours
Core Tip

Core Tip: Stem cell expansion in vitro is a routine procedure in stem cell-based therapy to achieve sufficient cells for transplantation. The potential of stem cell priming is crucial, offering a promising future for maintaining the cells’ survival, stemness, and repairability. The diverse priming strategies include physical, chemical, pharmacological, or genetic manipulation of the cells. Gu et al researched melatonin-induced priming of stem cells and the role of Yes-associated protein signaling in alleviating oxidative stress, reinforcing the priming strategy’s relevance and importance in cell-based therapy and instilling a sense of hope and optimism in the audience.