©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. May 26, 2023; 15(5): 438-452
Published online May 26, 2023. doi: 10.4252/wjsc.v15.i5.438
Published online May 26, 2023. doi: 10.4252/wjsc.v15.i5.438
Molecular signaling in cancer stem cells of tongue squamous cell carcinoma: Therapeutic implications and challenges
Priyanka Joshi, Sanjeev Waghmare, Stem Cell Biology Group, Cancer Research Institute, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai 410210, India
Author contributions: Waghmare S conceptualized the review article; Waghmare S and Joshi P wrote the manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest.
Corresponding author: Sanjeev Waghmare, PhD, Senior Scientist, Stem Cell Biology Group, Cancer Research Institute, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Sector 22, Utsav Chowk-CISF Road, Kharghar, Navi Mumbai 410210, India. swaghmare@actrec.gov.in
Received: December 22, 2022
Peer-review started: December 22, 2022
First decision: January 31, 2023
Revised: February 21, 2023
Accepted: April 7, 2023
Article in press: April 7, 2023
Published online: May 26, 2023
Processing time: 154 Days and 20.4 Hours
Peer-review started: December 22, 2022
First decision: January 31, 2023
Revised: February 21, 2023
Accepted: April 7, 2023
Article in press: April 7, 2023
Published online: May 26, 2023
Processing time: 154 Days and 20.4 Hours
Core Tip
Core Tip: Tongue squamous cell carcinoma is one of the most common and aggressive oral cavity carcinomas, particularly among the Indian population. Despite various treatment strategies employed, the survival rates of the patients remain poor. A rare population i.e., cancer stem cells (CSCs), plays an important role in resistance, recurrence as well as metastasis which are factors responsible for the poor survival outcome. In this review, we discuss the recent findings regarding cell signaling pathways and markers associated with the CSCs and the need to gain a deeper understanding on the properties of the CSCs.