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World J Stem Cells. Apr 26, 2023; 15(4): 235-247
Published online Apr 26, 2023. doi: 10.4252/wjsc.v15.i4.235
Role of brahma-related gene 1/brahma-associated factor subunits in neural stem/progenitor cells and related neural developmental disorders
Nai-Yu Ke, Tian-Yi Zhao, Wan-Rong Wang, Yu-Tong Qian, Chao Liu
Nai-Yu Ke, Wan-Rong Wang, Yu-Tong Qian, The First Clinical Medical College, Anhui Medical University, Hefei 230032, Anhui Province, China
Nai-Yu Ke, Tian-Yi Zhao, Wan-Rong Wang, Yu-Tong Qian, Chao Liu, Institute of Stem cells and Tissue Engineering, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui Province, China
Chao Liu, Department of Histology and Embryology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui Province, China
Author contributions: Ke NY and Zhao TY collected the data and wrote the manuscript; Wang WR and Qian YT collected the data; Liu C conceived the manuscript, collected the data, and wrote the manuscript.
Supported by the Natural Science Foundation of Anhui Province, No. 2008085MH251; Key Research and Development Project of Anhui Province, No. 202004J07020037; Anhui Provincial Institute of Translational Medicine, No. 2021zhyx-C19; and National Undergraduate Innovation and Entrepreneurship training program, No. 202010366016.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chao Liu, DPhil, Professor, Department of Histology and Embryology, School of Basic Medical Sciences, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui Province, China. chaol1974@ahmu.edu.cn
Received: December 24, 2022
Peer-review started: December 24, 2022
First decision: January 31, 2023
Revised: February 12, 2023
Accepted: March 20, 2023
Article in press: March 20, 2023
Published online: April 26, 2023
Processing time: 122 Days and 20.1 Hours
Core Tip

Core Tip: There are several reviews in the literature contributed to the role of BRG1/BRM-associated factor (BAF) complex in neural cell specification and neural development diseases. We review recent progress indicating that BAF complex plays an important role in neural stem/progenitor cells (NSPCs) during neural development and neural developmental disorders. More progresses in the role of BAF complex subunits in balancing self-renewal and differentiation of NSPCs and neurodevelopment could finally be involved in highlighting new methods for clinical application.