Molecular mechanism of therapeutic approaches for human gastric cancer stem cells

doi:10.4252/wjsc.v14.i1.76

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World Journal of Stem Cells

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World J Stem Cells. Jan 26, 2022; 14(1): 76-91
Published online Jan 26, 2022. doi: 10.4252/wjsc.v14.i1.76

Molecular mechanism of therapeutic approaches for human gastric cancer stem cells

Hsi-Lung Hsieh, Ming-Chin Yu, Li-Ching Cheng, Ta-Sen Yeh, Ming-Ming Tsai

Hsi-Lung Hsieh, Li-Ching Cheng, Ming-Ming Tsai, Department of Nursing, Division of Basic Medical Sciences, Chang-Gung University of Science and Technology, Taoyuan 333, Taiwan

Hsi-Lung Hsieh, Ming-Ming Tsai, Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan

Hsi-Lung Hsieh, Department of Neurology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan

Ming-Chin Yu, Ta-Sen Yeh, Department of General Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan

Ming-Chin Yu, Ta-Sen Yeh, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan

Ming-Chin Yu, Department of General Surgery, New Taipei Municipal TuCheng Hospital, New Taipei 236, Taiwan

Ming-Ming Tsai, Department of General Surgery, Chang Gung Memorial Hospital, Chiayi 613, Taiwan

Author contributions: All authors contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version; Hsieh HL, Yu MC and Cheng LC have contributed equally to this work.

Supported by the Ministry of Science and Technology, Taiwan, No. MOST 108-2320-B-255-002-MY3; Chang Gung Medical Research Foundation, Taoyuan, Taiwan No. CMRPF1I0031, No. CMRPF1I0041, No. CMRPF1I0041-2, and No. CMRPF1L0021; and Chang Gung University of Science and Technology, Taoyuan, Taiwan, No. ZRRPF3J0081, No. ZRRPF3K0111, and No. ZRRPF3L0091.

Conflict-of-interest statement: The author has no conflict of interest to declare.

Corresponding author: Ming-Ming Tsai, PhD, Associate Professor, Department of Nursing, Division of Basic Medical Sciences, Chang-Gung University of Science and Technology, No. 261 Wen-hwa 1 Road, Taoyuan 333, Taiwan. mmtsai@mail.cgust.edu.tw

Received: April 18, 2021
Peer-review started: April 18, 2021
First decision: May 12, 2021
Revised: May 15, 2021
Accepted: December 21, 2021
Article in press: December 21, 2021
Published online: January 26, 2022
Processing time: 276 Days and 14.5 Hours

Core Tip

Core Tip: In recent years, cancer stem cells (CSCs) have become an extremely important subject in cancer biology. CSCs are considered to be a very small component of tumor tissues, which nevertheless have the capacity for self-renewal, differentiation, and epithelial–mesenchymal transition. CSCs can also explain the clinical phenomenon of resistance to chemotherapy or radiotherapy. Many studies have also found that CSCs are important for cancer initiation and metastasis and play a key role in cancer recurrence. Here, we review GCSC (gastric cancer stem cell)-targeting therapies in GC, including information on GCSC-surface/intracellular markers and GCSC-mediated pathways. This review also provides a brief description of the GCSC niche. Understanding the molecular mechanism of GCSC-targeting agents can help optimize the accuracy of diagnosis and prognosis and the selection of the most appropriate therapy for GC patients.