Insight into generation of induced mesenchymal stem cells from induced pluripotent cells

doi:10.4252/wjsc.v14.i1.142

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jan 26, 2022; 14(1): 142-145
Published online Jan 26, 2022. doi: 10.4252/wjsc.v14.i1.142

Insight into generation of induced mesenchymal stem cells from induced pluripotent cells

Mahmood S Choudhery, Ruhma Mahmood

Mahmood S Choudhery, Department of Biomedical Sciences, King Edward Medical University, Lahore 54000, Punjab, Pakistan

Mahmood S Choudhery, Department of Genetics and Molecular Biology, University of Health Sciences, Lahore 54600, Punjab, Pakistan

Ruhma Mahmood, Stem Cells Laboratory, Allama Iqbal Medical College, Lahore 54000, Punjab, Pakistan

Author contributions: Choudhery MS and Mahmood R searched the literature and designed and wrote the manuscript.

Conflict-of-interest statement: The authors do not have any financial conflict of interest.

Corresponding author: Mahmood S Choudhery, PhD, Tenured Associate Professor, Department of Genetics and Molecular Biology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore 54600, Punjab, Pakistan. ms20031@yahoo.com

Received: September 9, 2021
Peer-review started: September 9, 2021
First decision: October 17, 2021
Revised: October 25, 2021
Accepted: December 23, 2021
Article in press: December 23, 2021
Published online: January 26, 2022
Processing time: 133 Days and 3 Hours

Core Tip

Core Tip: Regenerative potential of mesenchymal stem cells (MSCs) have been explored in a number of preclinical and clinical studies for the treatment of various diseases and disorders. However, factors such as low number of MSCs in donor tissues, heterogeneity, limited in vitro proliferative potential and early senescence in in vitro cultures restrict MSC use clinically. Novel methods to generate induced MSCs from induced pluripotent stem cells have been explored. Development and optimization of such protocols is necessary to evaluate the regenerative potential of induced MSCs in vivo and in vitro.