Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2021; 13(9): 1215-1230
Published online Sep 26, 2021. doi: 10.4252/wjsc.v13.i9.1215
Recent advances in stem cell therapy for neurodegenerative disease: Three dimensional tracing and its emerging use
Il-Kwon Kim, Jun-Hee Park, Bomi Kim, Ki-Chul Hwang, Byeong-Wook Song
Il-Kwon Kim, Jun-Hee Park, Bomi Kim, Ki-Chul Hwang, Byeong-Wook Song, Institute for Bio-Medical Convergence, Catholic Kwandong University International St. Mary’s Hospital, Incheon Metropolitan City 22711, South Korea
Il-Kwon Kim, Ki-Chul Hwang, Byeong-Wook Song, Institute for Bio-Medical Convergence, College of Medicine, Catholic Kwandong University, Gangwon-do 25601, South Korea
Author contributions: Kim IK and Park JH contributed equally to this work; Kim IK, Park JH, Kim B, Hwang KC, and Song BW wrote the manuscript; Song BW conceptualized the idea and reviewed and edited the article.
Supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MSIT), No. NRF-2020R1C1C1013535.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Byeong-Wook Song, PhD, Assistant Professor, Institute for Bio-Medical Convergence, Catholic Kwandong University International St. Mary’s Hospital, 25, Simgok-Ro 100 Beon-Gil, Seo-Gu, Incheon Metropolitan City 22711, South Korea. songbw@cku.ac.kr
Received: February 27, 2021
Peer-review started: February 27, 2021
First decision: May 5, 2021
Revised: May 20, 2021
Accepted: August 30, 2021
Article in press: August 30, 2021
Published online: September 26, 2021
Processing time: 202 Days and 10.3 Hours
Core Tip

Core Tip: Although the use of stem cells in neurodegenerative disease has become widespread, a proof of concept (PoC) for three-dimensional analysis of the interrelationships in brain structure has not been performed in vivo. This review will introduce recent stem cell research for therapies and PoC for a three-dimensional analysis based on tissue optical clearing.