©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Aug 26, 2021; 13(8): 1127-1133
Published online Aug 26, 2021. doi: 10.4252/wjsc.v13.i8.1127
Published online Aug 26, 2021. doi: 10.4252/wjsc.v13.i8.1127
Regulators of liver cancer stem cells
Kai Liu, Beijing Institute of Hepatology, Beijing You An Hospital, Capital Medical University, Beijing 100069, China
Jing-Hsiung James Ou, Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, United States
Author contributions: Both Liu K and Ou JHJ wrote the manuscript; both authors have read and approve the manuscript.
Supported by National Institutes of Health Grants , No. DK094652 and No. AI148304 .
Conflict-of-interest statement: The authors declare that there is no conflict of interest.
Corresponding author: Jing-Hsiung James Ou, PhD, Professor, Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, 2011 Zonal Avenue, HMR-401, Los Angeles, CA 90033, United States. jamesou@usc.edu
Received: March 1, 2021
Peer-review started: March 1, 2021
First decision: April 19, 2021
Revised: June 6, 2021
Accepted: July 30, 2021
Article in press: July 30, 2021
Published online: August 26, 2021
Processing time: 171 Days and 23.3 Hours
Peer-review started: March 1, 2021
First decision: April 19, 2021
Revised: June 6, 2021
Accepted: July 30, 2021
Article in press: July 30, 2021
Published online: August 26, 2021
Processing time: 171 Days and 23.3 Hours
Core Tip
Core Tip: Liver cancer stem cells (LCSCs) play a crucial role in the development of hepatocellular carcinoma (HCC), and their tumorigenicity and chemoresistance are major reasons as to why HCC is difficult to treat. LCSCs are regulated by a variety of factors. These factors include the network of pluripotency transcription factors, sig