©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jun 26, 2021; 13(6): 619-631
Published online Jun 26, 2021. doi: 10.4252/wjsc.v13.i6.619
Published online Jun 26, 2021. doi: 10.4252/wjsc.v13.i6.619
Biological, chemical and mechanical factors regulating migration and homing of mesenchymal stem cells
Renata Szydlak, Department of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kraków 31-034, Poland
Author contributions: Szydlak R wrote the paper.
Supported by National Center for Research and Development in Poland , No. STRATEGMED2/265761/10/NCBR/2015 .
Conflict-of-interest statement: The author declares having no conflict of interests for this article.
Corresponding author: Renata Szydlak, PhD, Postdoc, Research Assistant Professor, Department of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kopernika 7, Kraków 31-034, Poland. renata.szydlak@doctoral.uj.edu.pl
Received: February 27, 2021
Peer-review started: February 27, 2021
First decision: March 29, 2021
Revised: April 3, 2021
Accepted: May 17, 2021
Article in press: May 17, 2021
Published online: June 26, 2021
Processing time: 118 Days and 19.1 Hours
Peer-review started: February 27, 2021
First decision: March 29, 2021
Revised: April 3, 2021
Accepted: May 17, 2021
Article in press: May 17, 2021
Published online: June 26, 2021
Processing time: 118 Days and 19.1 Hours
Core Tip
Core Tip: Mesenchymal stem cells (MSCs) have been extensively studied for their therapeutic potential in clinical practice and regenerative medicine. MSCs can migrate towards damaged tissue and act as reservoirs for regenerative molecules and growth factors. Consequently, MSC-based therapies rely on the successful migration of these cells into the damaged tissue following administration. Here we look at the factors influencing the migration and colonization of damaged tissues by MSCs.