Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. May 26, 2021; 13(5): 386-415
Published online May 26, 2021. doi: 10.4252/wjsc.v13.i5.386
Programmed cell death in stem cell-based therapy: Mechanisms and clinical applications
Xi-Min Hu, Qi Zhang, Rui-Xin Zhou, Yan-Lin Wu, Zhi-Xin Li, Dan-Yi Zhang, Yi-Chao Yang, Rong-Hua Yang, Yong-Jun Hu, Kun Xiong
Xi-Min Hu, Qi Zhang, Rui-Xin Zhou, Yan-Lin Wu, Zhi-Xin Li, Dan-Yi Zhang, Yi-Chao Yang, Kun Xiong, Department of Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha 410013, Hunan Province, China
Xi-Min Hu, Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China
Rong-Hua Yang, Department of Burns, Fo Shan Hospital of Sun Yat-Sen University, Foshan 528000, Guangdong Province, China
Yong-Jun Hu, Department of Cardiovascular Medicine, Hunan People's Hospital (the First Affiliated Hospital of Hunan Normal University, Changsha 410005, Hunan Province, China
Author contributions: Hu XM was the major contributor in reviewing the literature, writing the manuscript, and creating descriptive figures; Zhou RX was a major contributor in editing the tables and figures; Wu YL, Hu YJ, and Li ZX assisted in literature review; Xiong K, Zhang Q, and Yang RH was a major contributor in revising the manuscript; all authors read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 81772134, No. 81971891, and No. 81571939.
Conflict-of-interest statement: Xiong K has received research funding from the National Natural Science Foundation of China.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kun Xiong, MD, PhD, Professor, Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, No. 172 Tongzi Po Road, Changsha 410013, Hunan Province, China. xiongkun2001@163.com
Received: February 26, 2021
Peer-review started: February 26, 2021
First decision: April 20, 2021
Revised: April 26, 2021
Accepted: May 7, 2021
Article in press: May 7, 2021
Published online: May 26, 2021
Processing time: 88 Days and 23.5 Hours
Core Tip

Core Tip: The point of interest of this work is the complex mechanisms of the programmed cell death in stem cells (SCs), which suggests a series of targets as an efficient, reliable, and potential strategy to promote the SC-based therapy.