Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Nov 26, 2021; 13(11): 1696-1713
Published online Nov 26, 2021. doi: 10.4252/wjsc.v13.i11.1696
Regulation of the mesenchymal stem cell fate by interleukin-17: Implications in osteogenic differentiation
Jelena Krstić, Slavko Mojsilović, Sonja S Mojsilović, Juan F Santibanez
Jelena Krstić, Gottfried Schatz Research Center, Medical University of Graz, Graz 8010, Austria
Slavko Mojsilović, Group for Hematology and Stem Cells, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade 11129, Serbia
Sonja S Mojsilović, Group for Immunology, Institute for Medical Research, National Institute of Republic of Serbia, Belgrade 11129, Serbia
Juan F Santibanez, Group for Molecular Oncology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade 11000, Serbia
Juan F Santibanez, Centro Integrativo de Biología y Química Aplicada, Universidad Bernardo O’Higgins, Chile 8370993, Chile
Author contributions: Santibanez JF designed the article; Santibanez JF and Mojsilović SS collected literature data; Santibanez JF,Krstić J and Mojsilović S wrote the paper.
Supported by Ministry of Education, Science and Technological Development of Serbia, No. 451-03-9/2021-14/200015; and Oesterreichische Nationalbank (Austrian Central Bank, Anniversary Fund), No. 18517 (to Krstić J).
Conflict-of-interest statement: The authors declare no potential conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Juan F Santibanez, PhD, Professor, Research Scientist, Group for Molecular Oncology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr. Subotića 4, Belgrade 11000, Serbia. jfsantibanez@imi.bg.ac.rs
Received: March 5, 2021
Peer-review started: March 5, 2021
First decision: May 5, 2021
Revised: May 14, 2021
Accepted: October 18, 2021
Article in press: October 18, 2021
Published online: November 26, 2021
Processing time: 264 Days and 22.9 Hours
Core Tip

Core Tip: The immune system closely interacts with the bone system in health and disease. Inflammation plays a strategic role in bone homeostasis and turnover. A proinflammatory cytokine interleukin-17 (IL-17) is produced in high amounts after bone damage and can influence mesenchymal stem cells’ fate toward early osteoprogenitor cells, either as a pro-osteogenic or an anti-osteogenic factor. Although these divergent IL-17 roles in bone formation are still not well understood, different conditions of the local microenvironment, the extent of inflammation, and the specific nature and stage of osteoprogenitor cells can influence the response to this cytokine, affecting the final cell differentiation outcome.