Systematic Reviews
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jul 26, 2020; 12(7): 659-675
Published online Jul 26, 2020. doi: 10.4252/wjsc.v12.i7.659
Role of stem cell therapies in treating chronic wounds: A systematic review
Anjali C Raghuram, Roy P Yu, Andrea Y Lo, Cynthia J Sung, Melissa Bircan, Holly J Thompson, Alex K Wong
Anjali C Raghuram, Roy P Yu, Andrea Y Lo, Cynthia J Sung, Melissa Bircan, Alex K Wong, Division of Plastic and Reconstructive Surgery, Keck School of Medicine of USC, Los Angeles, CA 90033, United States
Holly J Thompson, Wilson Dental Library, Herman Ostrow School of Dentistry of USC, Los Angeles, CA 90089, United States
Author contributions: Raghuram AC and Wong AK contributed to the study conception and design; Raghuram AC, Yu RP, Lo AY, Sung CJ, Bircan M and Thompson HJ contributed to literature review and analysis; Raghuram AC, Yu RP, Lo AY and Wong AK drafted, critically revised and edited the manuscript; Raghuram AC, Yu RP, Lo AY and Wong AK approved the final version.
Conflict-of-interest statement: While there is no conflict of interest relevant to this review article, we wish to disclose that Alex K. Wong’s laboratory receives research funding for pre-clinical wound healing studies from ACell, Inc.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Alex K Wong, MD, Associate Professor, Surgeon, Division of Plastic and Reconstructive Surgery, Keck School of Medicine of the University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033, United States. alex.wong@med.usc.edu
Received: February 26, 2020
Peer-review started: February 26, 2020
First decision: April 22, 2020
Revised: May 3, 2020
Accepted: May 27, 2020
Article in press: May 27, 2020
Published online: July 26, 2020
Processing time: 151 Days and 3.2 Hours
Core Tip

Core tip: Chronic wounds impose a significant burden on patients and the healthcare system with poor outcomes noted with the use of standard wound care protocols alone. Using stem cell therapies to treat these wounds results in improved cell signaling, release of growth factors and cytokines, neo-vessel formation, and immunomodulatory properties. Accordingly, patients experience enhanced healing of their formerly recalcitrant wounds. The objective of this review is to systematically evaluate the use of a wide range of stem cell therapies for the treatment of chronic wounds in order to guide providers in selecting appropriate treatment options for improved patient wound healing.