Basic Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Dec 26, 2020; 12(12): 1640-1651
Published online Dec 26, 2020. doi: 10.4252/wjsc.v12.i12.1640
Influence of donor age on the differentiation and division capacity of human adipose-derived stem cells
Cintia DS Horinouchi, María Julia Barisón, Anny W Robert, Crisciele Kuligovski, Alessandra M Aguiar, Bruno Dallagiovanna
Cintia DS Horinouchi, María Julia Barisón, Anny W Robert, Crisciele Kuligovski, Alessandra M Aguiar, Bruno Dallagiovanna, Stem Cells Basic Biology Laboratory, Instituto Carlos Chagas, Curitiba 81350010, Paraná, Brazil
Author contributions: Horinouchi CDS, Barisón MJ and Robert AW contributed equally to this work; Horinouchi CDS, Barisón MJ, Robert AW, de Aguiar AM and Dallagiovanna B designed and coordinated the study; Horinouchi CDS, Barisón MJ, Robert AW and Kuligovski C performed the experiments and acquired and analyzed data; Horinouchi CDS, Barisón MJ, Robert AW, Kuligovski C, de Aguiar AM and Dallagiovanna B interpreted the data; Horinouchi CDS, Barisón MJ and Robert AW wrote the manuscript; de Aguiar AM and Dallagiovanna B critically reviewed the manuscript; and all authors approved the final version of the article.
Supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico, No. 442353/2019-7 and No. 442375/2019-0.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board at Fundação Oswaldo Cruz.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bruno Dallagiovanna, PhD, Research Scientist, Stem Cells Basic Biology Laboratory, Instituto Carlos Chagas, Rua Professor Algacyr Munhoz Mader, 3775, Curitiba 81350010, Paraná, Brazil. bruno.dallagiovanna@fiocruz.br
Received: July 16, 2020
Peer-review started: July 16, 2020
First decision: August 9, 2020
Revised: October 9, 2020
Accepted: November 5, 2020
Article in press: November 5, 2020
Published online: December 26, 2020
Processing time: 163 Days and 8.5 Hours
Core Tip

Core Tip: Adipose-derived stem cells are adult multipotent stem cells with great therapeutic potential for a variety of diseases. The donor’s intrinsic characteristics, such as sex, health conditions and age, have been claimed to be the main factors responsible for affecting the quality and the performance of these cells. Regarding donor age, the literature shows many conflicting observations. Here, we evaluated the proliferation and differentiation potential of adipose-derived stem cells isolated from lipoaspirates obtained from elderly and young female donors. Our results demonstrated that age does not seem to significantly affect the cell division or adipogenic or osteogenic potential of these cells.