Zhou YK, Zhu LS, Huang HM, Cui SJ, Zhang T, Zhou YH, Yang RL. Stem cells from human exfoliated deciduous teeth ameliorate concanavalin A-induced autoimmune hepatitis by protecting hepatocytes from apoptosis. World J Stem Cells 2020; 12(12): 1623-1639 [PMID: 33505604 DOI: 10.4252/wjsc.v12.i12.1623]
Corresponding Author of This Article
Rui-Li Yang, DDS, PhD, Assistant Professor, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, No. 22 Zhongguancun South Avenue, Beijing 100081, China. ruiliyangabc@163.com
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Yi-Kun Zhou, Hua-Ming Huang, Sheng-Jie Cui, Ting Zhang, Yan-Heng Zhou, Rui-Li Yang, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China
Ling-Su Zhu, Department of Orthodontics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Author contributions: Zhou YK, Yang RL, Zhu LS, and Zhou YH designed the research study; Zhou YK, Yang RL, Zhu LS, and Huang HM performed the research; Cui SJ and Zhang T contributed new reagents and analytic tools; Zhou YK and Yang RL analyzed the data and wrote the manuscript; all authors have read and approved the final manuscript.
Supported byThe National Natural Science Foundation of China, No. 81970940 and No. 81600865; Beijing Natural Science Foundation, No. 7182182; and the National Science and Technology Major Project of the Ministry of Science and Technology of China, No. 2018ZX10302207.
Institutional animal care and use committee statement: This study was approved by the Animal Care and Use Committee of the Health Science Center, Peking University (No. 2015-186).
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: Data are available upon reasonable request from R L Yang at ruiliyangabc@163.com
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rui-Li Yang, DDS, PhD, Assistant Professor, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, No. 22 Zhongguancun South Avenue, Beijing 100081, China. ruiliyangabc@163.com
Received: May 31, 2020 Peer-review started: May 31, 2020 First decision: August 22, 2020 Revised: September 20, 2020 Accepted: October 12, 2020 Article in press: October 12, 2020 Published online: December 26, 2020 Processing time: 210 Days and 1.6 Hours
Core Tip
Core Tip: Autoimmune hepatitis poses an enhancing global burden, underscoring the need to identify novel treatments. To determine the effects of stem cells from human exfoliated deciduous teeth (SHED) on concanavalin A (ConA)-induced autoimmune hepatitis, we pretreated ConA-induced hepatitis mice with SHED. SHED blocked increased expression of alanine aminotransferase and aspartate aminotransferase, and prevented aberrant histopathological liver architecture due to infiltration of CD3+, CD4+, tumor necrosis-alpha+, and interferon-gamma+ inflammatory cells. ConA upregulated nuclear factor-kappa B-activated tumor necrosis-alpha and interferon-gamma expression, inducing hepatocyte apoptosis and acute liver injury. SHED administration protected hepatocytes from apoptosis, providing a potential treatment for hepatitis and acute hepatic injury.
