Review
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Dec 26, 2020; 12(12): 1439-1454
Published online Dec 26, 2020. doi: 10.4252/wjsc.v12.i12.1439
Brain tumors: Cancer stem-like cells interact with tumor microenvironment
Hai-Long Liu, Ya-Nan Wang, Shi-Yu Feng
Hai-Long Liu, Shi-Yu Feng, Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China
Ya-Nan Wang, Department of Pathology, Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, China
Author contributions: Liu HL and Wang YN contributed equally to the review; Liu HL and Feng SY contributed to the whole conception and design; Liu HL and Wang YN were responsible for the details of the review structure and interpretation; Liu HL, Wang YN, and Feng SY completed the manuscript and figures; Feng SY was responsible for the review supervision; all authors read and approved the final version of the manuscript.
Supported by The Medical Big Data Research Program of Chinese PLA General Hospital, No. 2018MBD-20 (to Feng SY); National Natural Science Foundation of China, No. 81902975 (to Liu HL); and the 65th China Postdoctoral Science Foundation, No. 2019M653940 (to Liu HL).
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shi-Yu Feng, MD, PhD, Doctor, Department of Neurosurgery, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. fengshiyu72123@163.com
Received: March 29, 2020
Peer-review started: March 30, 2020
First decision: September 21, 2020
Revised: October 7, 2020
Accepted: October 27, 2020
Article in press: October 27, 2020
Published online: December 26, 2020
Processing time: 272 Days and 19.5 Hours
Core Tip

Core Tip: To better understand the effects of interplaying between cancer stem-like cells (CSCs) and tumor microenvironment (TME) on brain tumor progression, we review the distinct characters of CSCs and the mechanisms regarding how TME regulates CSC self-renewal. Moreover, we emphasize the valuable application of sing-cell RNA sequencing technology in the cancer research.