Zhang GL, Qian C, Zhang SZ, Tuo YH, Zeng BY, Ji YX, Wang YZ. Effect of conditioned medium from neural stem cells on glioma progression and its protein expression profile analysis. World J Stem Cells 2020; 12(11): 1396-1409 [PMID: 33312406 DOI: 10.4252/wjsc.v12.i11.1396]
Corresponding Author of This Article
Ye-Zhong Wang, MD, PhD, Chairman, Chief Doctor, Professor, Department of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, No. 250 East Changgang Road, Haizhu District, Guangzhou 510260, Guangdong Province, China. wangyezhong@gzhmu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Basic Study
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Zhang GL, Qian C, Zhang SZ, Tuo YH, Zeng BY, Ji YX, Wang YZ. Effect of conditioned medium from neural stem cells on glioma progression and its protein expression profile analysis. World J Stem Cells 2020; 12(11): 1396-1409 [PMID: 33312406 DOI: 10.4252/wjsc.v12.i11.1396]
World J Stem Cells. Nov 26, 2020; 12(11): 1396-1409 Published online Nov 26, 2020. doi: 10.4252/wjsc.v12.i11.1396
Effect of conditioned medium from neural stem cells on glioma progression and its protein expression profile analysis
Gui-Long Zhang, Cheng Qian, Shi-Zhen Zhang, Yong-Hua Tuo, Bai-Yun Zeng, Yun-Xiang Ji, Ye-Zhong Wang
Gui-Long Zhang, Cheng Qian, Shi-Zhen Zhang, Yong-Hua Tuo, Bai-Yun Zeng, Yun-Xiang Ji, Ye-Zhong Wang, Department of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, Guangdong Province, China
Gui-Long Zhang, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province China
Author contributions: Zhang GL, Qian C, and Zhang SZ designed and performed the experiments; Ji YX and Wang YZ contributed to data analysis; Zhang SZ, Tuo YH, and Zeng BY performed the experiments; Zhang GL, Qian C, and Zhang SZ wrote the paper, Ji YX and Wang YZ edited the manuscript; all authors have approved the final manuscript; Zhang GL, Qian C, and Zhang SZ contributed equally to this work.
Supported byChina Postdoctoral Science Foundation, No. 2020M672592 and No. 2019TQ0071.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board at Affiliated Zhongda Hospital of Southeast University.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Corresponding author: Ye-Zhong Wang, MD, PhD, Chairman, Chief Doctor, Professor, Department of Neurosurgery, The Second Affiliated Hospital of Guangzhou Medical University, No. 250 East Changgang Road, Haizhu District, Guangzhou 510260, Guangdong Province, China. wangyezhong@gzhmu.edu.cn
Received: June 1, 2020 Peer-review started: June 1, 2020 First decision: August 22, 2020 Revised: September 4, 2020 Accepted: September 25, 2020 Article in press: September 25, 202 Published online: November 26, 2020 Processing time: 178 Days and 3.5 Hours
Core Tip
Core Tip: The cell communications or crosstalk between glioma cells and non-glioma cells in the tumor microenvironment plays dominant roles in tumor therapy. The subventricular zone (SVZ) neural stem cells (NSCs) have been shown to be closely associated with glioma progression and recurrence. Interestingly, the conditioned medium (CM) from SVZ NSCs significantly promoted glioma cell proliferation and invasion, with oxygen-glucose deprived NSC-CM showing enhanced effects. Furthermore, the secreted protein NCAN presented in oxygen-glucose deprived NSC-CM played important roles in the progression of glioma cells mainly via the Rho/Rho-associated protein kinase pathway. Overall, this study provided important insights into the potential therapeutic application of NCAN derived from SVZ NSCs in the treatment of glioma.
