©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Aug 26, 2019; 11(8): 464-475
Published online Aug 26, 2019. doi: 10.4252/wjsc.v11.i8.464
Published online Aug 26, 2019. doi: 10.4252/wjsc.v11.i8.464
Orchestrating stem cell fate: Novel tools for regenerative medicine
Sara Cruciani, Sara Santaniello, Andrea Montella, Margherita Maioli, Department of Biomedical Sciences, University of Sassari, Sassari 07100, Italy
Sara Cruciani, Sara Santaniello, Carlo Ventura, Margherita Maioli, Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems – Eldor Lab, Innovation Accelerator, Consiglio Nazionale delle Ricerche, Bologna 40129, Italy
Andrea Montella, Operative Unit of Clinical Genetics and Developmental Biology, Sassari 07100, Italy
Margherita Maioli, Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Cagliari 09042, Italy
Margherita Maioli, Center for Developmental Biology and Reprogramming-CEDEBIOR, Department of Biomedical Sciences, University of Sassari, Sassari 07100, Italy
Author contributions: All authors contributed in the design and writing of the paper, literature review and the analysis, revision and approval of the final version.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Corresponding author: Margherita Maioli, PhD, Professor, Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, Sassari 07100, Italy. mmaioli@uniss.it
Telephone: +39-07-9228277
Received: February 20, 2019
Peer-review started: February 20, 2019
First decision: April 15, 2019
Revised: May 28, 2019
Accepted: June 12, 2019
Article in press: June 12, 2019
Published online: August 26, 2019
Processing time: 187 Days and 19.6 Hours
Peer-review started: February 20, 2019
First decision: April 15, 2019
Revised: May 28, 2019
Accepted: June 12, 2019
Article in press: June 12, 2019
Published online: August 26, 2019
Processing time: 187 Days and 19.6 Hours
Core Tip
Core tip: The latest advances in the field of stem cells concern epigenetics and its role in self-renewal and differentiation capability. Activation or silencing of genes controlling stemness and tissue-lineage specification are related to chromatin-remodeling factors and epigenetic regulators. In this review, we focused on the principal epigenetic markers that regulate stem cell pluripotency, in vitro manipulation and the current state-of-the-art in vivo applications of human mesenchymal stem cells.