Human cord blood-derived viral pathogens as the potential threats to the hematopoietic stem cell transplantation safety: A mini review

doi:10.4252/wjsc.v11.i2.73

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Feb 26, 2019; 11(2): 73-83
Published online Feb 26, 2019. doi: 10.4252/wjsc.v11.i2.73

Human cord blood-derived viral pathogens as the potential threats to the hematopoietic stem cell transplantation safety: A mini review

Ali Noroozi-aghideh, Maryam Kheirandish

Ali Noroozi-aghideh, Department of Hematology, Faculty of Paramedicine, Aja University of Medical Sciences, Tehran 14665-1157, Iran

Maryam Kheirandish, Immunology Department, Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine (IBTO), Tehran 14665-1157, Iran

Author contributions: The author contributed equally to this work.

Conflict-of-interest statement: Authors of this manuscript have no conflicts of interest to disclose.

Corresponding author: Maryam Kheirandish, PhD, Associate Professor, Immunology Department, Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine (IBTO), Hemmat high way next to Milad tower, Tehran 14665-1157, Iran. m.kheirandish@ibto.ir

Telephone: +98-21-88629538 Fax: +98-21-88601577

Received: December 12, 2018
Peer-review started: December 12, 2018
First decision: December 24, 2018
Revised: January 14, 2019
Accepted: January 26, 2019
Article in press: January 26, 2019
Published online: February 26, 2019
Processing time: 76 Days and 18.1 Hours

Core Tip

Core tip: Severe infectious complications, especially due to viral pathogens remain the leading cause of the post-transplantation morbidity and mortality. In this context, excluding the viral-contaminated umbilical cord blood (UCB) units might be an effective policy to reduce the infection rate after UCB transplantation (UCBT). Complete prevention of the transmission of donor-derived viral pathogens via UCB is not possible. However, having the knowledge of the transmission route and the prevalence of viruses will improve the transplantation safety by controlled patient management. This minireview summarizes the general aspects concerning the prevalence, characteristics and risk factors of viral infections with a focus on the impact on UCBT safety.