Small molecules for mesenchymal stem cell fate determination

doi:10.4252/wjsc.v11.i12.1084

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Dec 26, 2019 (publication date) through Feb 16, 2026

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Dec 26, 2019; 11(12): 1084-1103
Published online Dec 26, 2019. doi: 10.4252/wjsc.v11.i12.1084

Small molecules for mesenchymal stem cell fate determination

Yu-Hao Cheng, Jing-Cheng Dong, Qin Bian

Yu-Hao Cheng, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States

Jing-Cheng Dong, Qin Bian, Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China

Author contributions: Cheng YH wrote the manuscript; Dong JC and Bian Q edited the manuscript and provided feedback.

Supported by the National Natural Science Foundation of China, No. 81573992.

Conflict-of-interest statement: The author has no conflict of interest to declare.

Corresponding author: Qin Bian, MD, PhD, Department of Integrative Medicine, Huashan Hospital, Fudan University, No. 12 Middle Urumqi Road, Shanghai 200040, China. bianqin213@126.com

Telephone: 86-21-52889999

Received: March 26, 2019
Peer-review started: March 28, 2019
First decision: April 15, 2019
Revised: September 13, 2019
Accepted: October 14, 2019
Article in press: October 14, 2019
Published online: December 26, 2019
Processing time: 247 Days and 16 Hours

Core Tip

Core tip: Mesenchymal stem cells (MSCs), also called MSCs, are adult stem cells with multilineage differentiation potential. They serve crucial physiological roles, regulating the bone marrow microenvironment and adipose tissue remodeling in vivo. A complex regulatory network and signaling pathways are involved in governing MSC fate commitment. Much progress has been made in recent years in discovering small molecules and their underlying mechanisms that control the cell fate of MSCs. In this review, we summarize recent findings in applying small molecules to the trilineage cell fate commitment of MSCs, highlighting the underlying mechanisms and the current clinical trials. The small molecules for MSC fate determination offer substantial insights into bone marrow and adipose tissue homeostasis and therapeutic strategies for MSC-related diseases.