©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2018; 10(9): 119-133
Published online Sep 26, 2018. doi: 10.4252/wjsc.v10.i9.119
Published online Sep 26, 2018. doi: 10.4252/wjsc.v10.i9.119
Regulatory role of sphingosine kinase and sphingosine-1-phosphate receptor signaling in progenitor/stem cells
Mei Li Ng, Centenary Institute of Cancer Medicine and Cell Biology, Sydney NSW 2050, Australia
Nagendra S Yarla, Department of Biochemistry and Bioinformatics, Institute of Science, GITAM University, Rushikonda, Visakhapatnam 530 045, Andhra Pradesh, India
Mario Menschikowski, Institute of Clinical Chemistry and Laboratory Medicine, Carl Gustav Carus University Hospital, Technical University of Dresden, Dresden D-01307, Germany
Olga A Sukocheva, College of Nursing and Health Sciences, Flinders University of South Australia, Bedford Park SA 5042, Australia
Author contributions: Sukocheva OA and Menschikowski M conceptualized the original idea, designed the review concept, and wrote introductory and conclusive parts of the study; Ng ML and Yarla NS collected the required data and wrote different chapters of the manuscript; Sukocheva OA and Ng ML drew the figures; all authors read and approved the final manuscript.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Correspondence to: Olga A Sukocheva, MSc, PhD, Lecturer, College of Nursing and Health Sciences, Flinders University of South Australia, Flinders Drive, Bedford Park SA 5042, Australia. olga.sukocheva@flinders.edu.au
Telephone: +61-8-82013648 Fax: +61-8-82017500
Received: April 27, 2018
Peer-review started: April 27, 2018
First decision: June 6, 2018
Revised: July 27, 2018
Accepted: August 5, 2018
Article in press: August 5, 2018
Published online: September 26, 2018
Processing time: 152 Days and 1 Hours
Peer-review started: April 27, 2018
First decision: June 6, 2018
Revised: July 27, 2018
Accepted: August 5, 2018
Article in press: August 5, 2018
Published online: September 26, 2018
Processing time: 152 Days and 1 Hours
Core Tip
Core tip: The aim of this study is to review the role of sphingosine kinase, sphingosine-1-phosphate (S1P), and its receptors in the regulation of stem/progenitor cell function. Our analysis indicates that S1P receptor expression, localization, and specific downstream effectors influence the rate of self-renewal and differentiation of myogenic, hematopoietic, endothelial, neural, and cancer progenitor cells.