Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Optimizing mesenchymal stem cell therapy for tendon-bone healing: Multifaceted approaches and future directions
Han Li, Zhi-Peng Li, Meng-Ting Zhu, Chen-Hao Lan, Yu-Xin Wang, Ping Liao, Zheng Chen, Peng Wang, Jin-Ke Sun, Zhen Shi, Peng-Yu Lu, Chao Lou, Guo-Hong Xu
Han Li, Chen-Hao Lan, Yu-Xin Wang, Ping Liao, Zheng Chen, Chao Lou, Guo-Hong Xu, Department of Orthopedics, Affiliated Dongyang Hospital of Wenzhou Medical University, Jinhua 322100, Zhejiang Province, China
Zhi-Peng Li, Peng Wang, Zhen Shi, Second Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Zhi-Peng Li, Tianjian Advanced Biomedical Laboratory, Zhengzhou University, Zhengzhou 450001, Henan Province, China
Meng-Ting Zhu, Department of Neurology, Union Medical College Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China
Jin-Ke Sun, Third Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Peng-Yu Lu, First Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Co-first authors: Han Li and Zhi-Peng Li.
Co-corresponding authors: Chao Lou and Guo-Hong Xu.
Author contributions: Li H and Li ZP contributed equally to the development and writing of this review and are therefore recognized as co-first authors; Li H and Li ZP conceptualized and designed the study; Zhu MT, Lan CH, Wang YX, and Liao P conducted the literature review, extracted and analyzed key references, and drafted the initial manuscript; Chen Z, Wang P, Sun JK, and Shi Z prepared the figures and graphical illustrations; Lu PY critically revised the manuscript for intellectual content and contributed to methodological refinement; Lou C and Xu GH jointly supervised the entire project, critically reviewed and finalized the manuscript, and secured research funding; hence, they are recognized as co-corresponding authors. The collaboration between Lou C and Xu GH was essential to the successful completion and publication of this work.
Supported by Jinhua Public Welfare Technology Application Research Project, No. 2025-4-229; and Zhejiang Province Medical and Health Science and Technology Plan, No. 2022KY1343.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Guo-Hong Xu, Chief Physician, Professor, Department of Orthopedics, Affiliated Dongyang Hospital of Wenzhou Medical University, No. 60 Wuning West Road, Jinhua 322100, Zhejiang Province, China.
xgh316@163.com
Received: September 11, 2025
Revised: October 12, 2025
Accepted: November 11, 2025
Published online: December 26, 2025
Processing time: 105 Days and 13.5 Hours
