Recent progress in hair follicle stem cell markers and their regulatory roles

doi:10.4252/wjsc.v16.i2.126

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Feb 26, 2024 (publication date) through Mar 12, 2026

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World Journal of Stem Cells

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1948-0210

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World J Stem Cells. Feb 26, 2024; 16(2): 126-136
Published online Feb 26, 2024. doi: 10.4252/wjsc.v16.i2.126

Recent progress in hair follicle stem cell markers and their regulatory roles

Yi-Zhan Xing, Hai-Ying Guo, Fei Xiang, Yu-Hong Li

Yi-Zhan Xing, Hai-Ying Guo, Yu-Hong Li, Department of Cell Biology, Army Medical University, Chongqing 400038, China

Fei Xiang, Institute of Burn Research, Southwest Hospital, Army Medical University, Chongqing 400038, China

Author contributions: Xing YZ drafted the manuscript; Guo HY and Xiang F participated in the literature sorting; Guo HY prepared the table; Xiang F was involved in preparation of the figure; Li YH conceived and revised the manuscript; and all authors have read and approve the final manuscript.

Supported by National Natural Science Foundation of China, No. 82173446; and the Youth Training Program of the Army Medical University, No. 2018XQN01.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Yu-Hong Li, PhD, Associate Professor, Department of Cell Biology, Army Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing 400038, China. liyuhongtmmu@hotmail.com

Received: October 27, 2023
Peer-review started: October 27, 2023
First decision: December 5, 2023
Revised: December 19, 2023
Accepted: January 16, 2024
Article in press: January 16, 2024
Published online: February 26, 2024
Processing time: 122 Days and 2.4 Hours

Abstract

Hair follicle stem cells (HFSCs) in the bulge are a multipotent adult stem cell population. They can periodically give rise to new HFs and even regenerate the epidermis and sebaceous glands during wound healing. An increasing number of biomarkers have been used to isolate, label, and trace HFSCs in recent years. Considering more detailed data from single-cell transcriptomics technology, we mainly focus on the important HFSC molecular markers and their regulatory roles in this review.

Keywords: Hair follicle stem cells; Bulge; Secondary hair germ; Marker; Single-cell RNA-sequencing

Core Tip: Hair follicle stem cells (HFSCs) in the bulge are a multipotent adult stem cell population. They can periodically give rise to new HFs and even regenerate the epidermis and sebaceous glands during wound healing. An increasing number of biomarkers have been used to isolate, label, and trace HFSCs in recent years. Considering more detailed data from single-cell transcriptomics technology, we mainly focus on the important HFSC molecular markers and their regulatory roles in this review.