Treatment of acute ischemic stroke by minimally manipulated umbilical cord-derived mesenchymal stem cells transplantation: A case report

doi:10.4252/wjsc.v13.i8.1151

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World Journal of Stem Cells

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Case Report

World J Stem Cells. Aug 26, 2021; 13(8): 1151-1159
Published online Aug 26, 2021. doi: 10.4252/wjsc.v13.i8.1151

Treatment of acute ischemic stroke by minimally manipulated umbilical cord-derived mesenchymal stem cells transplantation: A case report

Hyunjun Ahn, Sang Yeon Lee, Won Ju Jung, Kye-Ho Lee

Hyunjun Ahn, Sang Yeon Lee, Kye-Ho Lee, bio Beauty&Health Company (bBHC)-Stem Cell Treatment & Research Institute (STRI), Seoul 04420, South Korea

Won Ju Jung, 97.7 Beauty&Health (B&H) Clinics, Seoul 04420, South Korea

Author contributions: Ahn H, Lee SY, Jung WJ, and Lee KH designed the reports; Ahn H and Jung WJ collected the patients’ clinical data; Ahn H, Lee SY, and Jung WJ analyzed the data; Ahn H wrote the manuscript; Lee KH provided professional advice and revised the manuscript; all authors issued final approval for the version to be submitted.

Informed consent statement: The patients involved in this study gave their written informed consent authorizing disclosure of protected health information.

Conflict-of-interest statement: All authors have no conflicts of interest to declare.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Corresponding author: Kye-Ho Lee, PhD, bio Beauty&Health Company (bBHC) - Stem Cell Treatment & Research Institute (STRI), 72 UN village-gil Yongsan-gu, Seoul 04420, South Korea. khlee@stc365.com

Received: May 21, 2021
Peer-review started: May 21, 2021
First decision: June 16, 2021
Revised: June 23, 2021
Accepted: August 6, 2021
Article in press: August 6, 2021
Published online: August 26, 2021
Processing time: 91 Days and 0.4 Hours

Abstract

BACKGROUND

Stroke is one of the major causes of disability and death worldwide. Some treatments for stroke exist, but existing treatment methods have limitations such as difficulty in the regeneration of damaged neuronal cells of the brain. Recently, mesenchymal stem cells (MSCs) have been studied as a therapeutic alternative for stroke, and various preclinical and case studies have been reported.

CASE SUMMARY

A 55-year-old man suffered an acute stroke, causing paralysis in the left upper and lower limbs. He intravenously transplanted the minimally manipulated human umbilical cord-derived MSCs (MM-UC-MSCs) twice with an 8-d interval. At 65 wk after transplantation, the patient returned to his previous occupation as a veterinarian with no adverse reactions.

CONCLUSION

MM-UC-MSCs transplantation potentially treats patients who suffer from acute ischemic stroke.

Keywords: Acute ischemic stroke; Behavioral disorder; Umbilical cord-derived mesenchymal stem cells; Allogenic; Cell therapy; Minimal manipulation; Case report

Core Tip: Previous results of preclinical and case studies showed the effectiveness of mesenchymal stem cells (MSCs) transplantation to stroke patients. In this case study, the patient who suffered from acute ischemic stroke was successfully treated using allogenic, minimally manipulated human umbilical cord-derived MSCs. This is the first report of using minimally manipulated human umbilical cord-derived MSCs to treat acute ischemic stroke.