Stem cell-based therapies for fertility preservation in males: Current status and future prospects

doi:10.4252/wjsc.v12.i10.1097

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Oct 26, 2020 (publication date) through Feb 26, 2026

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World Journal of Stem Cells

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World J Stem Cells. Oct 26, 2020; 12(10): 1097-1112
Published online Oct 26, 2020. doi: 10.4252/wjsc.v12.i10.1097

Stem cell-based therapies for fertility preservation in males: Current status and future prospects

Han-Chao Liu, Yun Xie, Chun-Hua Deng, Gui-Hua Liu

Han-Chao Liu, Yun Xie, Chun-Hua Deng, Department of Andrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China

Gui-Hua Liu, Reproductive Medicine Research Center, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, Guangdong Province, China

Author contributions: Liu HC and Xie Y contributed equally to this work; Liu HC, Xie Y, Deng CH, and Liu GH designed this paper; Liu HC and Xie Y wrote the paper; Deng CH made the picture; Liu GH revised the paper. All authors have read and approved the final manuscript.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Corresponding author: Gui-Hua Liu, MD, PhD, Associate Professor, Reproductive Medicine Research Center, The Sixth Affiliated Hospital of Sun Yat-sen University, No. 17 Sogoulin Road, Guangzhou 510655, Guangdong Province, China. lgh99707@163.com

Received: February 26, 2020
Peer-review started: February 26, 2020
First decision: April 9, 2020
Revised: May 13, 2020
Accepted: August 25, 2020
Article in press: August 25, 2020
Published online: October 26, 2020
Processing time: 242 Days and 17.4 Hours

Abstract

With the decline in male fertility in recent years, strategies for male fertility preservation have received increasing attention. In this study, by reviewing current treatments and recent publications, we describe research progress in and the future directions of stem cell-based therapies for male fertility preservation, focusing on the use of spermatogonial stem cells (SSCs), SSC niches, SSC-based testicular organoids, other stem cell types such as mesenchymal stem cells, and stem cell-derived extracellular vesicles. In conclusion, a more comprehensive understanding of the germ cell microenvironment, stem cell-derived extracellular vesicles, and testicular organoids will play an important role in achieving male fertility preservation.

Keywords: Fertility preservation; Sperm cryopreservation; Spermatogonial stem cell; Testicular organoids; Stem cell; Extracellular vesicles

Core Tip: With the decline in male fertility in recent years, strategies for male fertility preservation have received increasing attention. In this study, by reviewing current treatments and recent publications, we describe research progress in and the future directions of stem cell-based therapies for male fertility preservation, focusing on the use of spermatogonial stem cells (SSCs), SSC niches, SSC-based testicular organoids, other stem cell types such as mesenchymal stem cells, and extracellular vesicles derived from stem cells.