| For: | Yang HC, Zhang M, Wu R, Zheng HQ, Zhang LY, Luo J, Li LL, Hu XQ. C-C chemokine receptor type 2-overexpressing exosomes alleviated experimental post-stroke cognitive impairment by enhancing microglia/macrophage M2 polarization. World J Stem Cells 2020; 12(2): 152-167 [PMID: 32184939 DOI: 10.4252/wjsc.v12.i2.152] |
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| URL: | https://www.wjgnet.com/1948-0210/full/v12/i2/152.htm |
| Number | Citing Articles |
| 1 |
Bart de Jong, Eric Raul Barros, Joost G. J. Hoenderop, Juan Pablo Rigalli. Recent Advances in Extracellular Vesicles as Drug Delivery Systems and Their Potential in Precision Medicine. Pharmaceutics 2020; 12(11) doi: 10.3390/pharmaceutics12111006
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| 2 |
Powsali Ghosh, Ravi Singh, Ankit Ganeshpurkar, Ankit Vyankatrao Pokle, Ravi bhushan Singh, Sushil Kumar Singh, Ashok Kumar. Cellular and molecular influencers of neuroinflammation in Alzheimer's disease: Recent concepts & roles. Neurochemistry International 2021; 151 doi: 10.1016/j.neuint.2021.105212
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| 3 |
Yasna Shahsavandi, Farina Banaeian, Morteza Jafarinia, Fatemeh Nasri, Shima Shapoori. miRNAs from mesenchymal-stem-cell-derived extracellular vesicles: Emerging players in regenerative medicine and disease therapy. Molecular Therapy Nucleic Acids 2025; 36(4) doi: 10.1016/j.omtn.2025.102715
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| 4 |
Fatemeh Mehryab, Fatemeh Taghizadeh, Nazanin Goshtasbi, Faezeh Merati, Shahram Rabbani, Azadeh Haeri. Exosomes as cutting-edge therapeutics in various biomedical applications: An update on engineering, delivery, and preclinical studies. Biochimie 2023; 213 doi: 10.1016/j.biochi.2023.05.010
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| 5 |
Fatemeh Tahmasebi, Shirin Barati. The Role of Microglial Depletion Approaches in Pathological Condition of CNS. Cellular and Molecular Neurobiology 2023; 43(6) doi: 10.1007/s10571-023-01326-8
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| 6 |
Sanghun Lee, Ok Joon Kim, Kee Ook Lee, Hyeju Jung, Seung-Hun Oh, Nam Keun Kim. Enhancing the Therapeutic Potential of CCL2-Overexpressing Mesenchymal Stem Cells in Acute Stroke. International Journal of Molecular Sciences 2020; 21(20) doi: 10.3390/ijms21207795
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| 7 |
Eun Jeong Park, Phyoe Kyawe Myint, Michael G. Appiah, Patsorn Worawattananutai, Janjira Inprasit, Onmanee Prajuabjinda, Zay Yar Soe, Arong Gaowa, Eiji Kawamoto, Motomu Shimaoka. Ligand-competent fractalkine receptor is expressed on exosomes. Biochemistry and Biophysics Reports 2021; 26 doi: 10.1016/j.bbrep.2021.100932
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| 8 |
Arshia Arbabian, Tristan Driscoll, Yan Li, Samuel C. Grant. Potential of intranasal delivery of human mesenchymal stem cells and extracellular vesicles for stroke therapy. Acta Biomaterialia 2026; 214 doi: 10.1016/j.actbio.2026.02.049
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| 9 |
Rui Gu, Liping Jiang, Shuqin Dai, Yajie Yue, Shangjin Li, Shudan Zheng, Liwei Wu, Shaojie Zhao. Identification of exosome-related SERPINB1 as a novel predictor for tumor immune microenvironment and clinical outcomes in ovarian cancer. Journal of Ovarian Research 2025; 18(1) doi: 10.1186/s13048-025-01589-3
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| 10 |
Yuying Guo, Dongsheng Hu, Lu Lian, Linna Zhao, Mingli Li, Huijing Bao, Shixin Xu. Stem Cell-derived Extracellular Vesicles: A Promising Nano Delivery Platform to the Brain?. Stem Cell Reviews and Reports 2023; 19(2) doi: 10.1007/s12015-022-10455-4
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| 11 |
Overcoming biological barriers: Precision engineered extracellular vesicles for personalized neuromedicine. Precision Medicine and Engineering 2024; 1(2) doi: 10.1016/j.preme.2024.100010
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| 12 |
Ivonne Salinas, Laura Vela, Shabnam Santos, Ariel Moncayo, Kevin Moreno, Auki Guaillas, Ramiro F. Diaz, Andrés Caicedo. MSC-derived exosomes for hemorrhagic stroke: preclinical evidence and translational challenges. Frontiers in Neurology 2026; 17 doi: 10.3389/fneur.2026.1711050
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| 13 |
Lei Hao, Yongtao Yang, Xiaoli Xu, Xiuming Guo, Qunling Zhan. Modulatory effects of mesenchymal stem cells on microglia in ischemic stroke. Frontiers in Neurology 2023; 13 doi: 10.3389/fneur.2022.1073958
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| 14 |
Ke Li, Zhu Zhu, Xiumei Sun, Linhong Zhao, Zuolong Liu, Jihong Xing. Harnessing the therapeutic potential of mesenchymal stem cell-derived exosomes in cardiac arrest: Current advances and future perspectives. Biomedicine & Pharmacotherapy 2023; 165 doi: 10.1016/j.biopha.2023.115201
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| 15 |
Qian Jin, Peipei Wu, Xinru Zhou, Hui Qian, Wenrong Xu, Faisal Alzahrani. Extracellular Vesicles: Novel Roles in Neurological Disorders. Stem Cells International 2021; 2021 doi: 10.1155/2021/6640836
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| 16 |
Shuhong Kuang, Feng He, Guihua Liu, Xiangzhou Sun, Jian Dai, Ani Chi, Yali Tang, Zhuoran Li, Yong Gao, Chunhua Deng, Zhengmei Lin, Haipeng Xiao, Min Zhang. CCR2-engineered mesenchymal stromal cells accelerate diabetic wound healing by restoring immunological homeostasis. Biomaterials 2021; 275 doi: 10.1016/j.biomaterials.2021.120963
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| 17 |
Luis Pedro Bernardi, Thomas Hugentobler Schlickmann, Giovanna Carello-Collar, Marco Antonio De Bastiani, Eduardo Rigon Zimmer, Elizandra Braganhol, Francieli Rohden, Diogo Onofre Souza. Microglial Responses to MSC-EVs Treatment in Animal and Cellular Models of Ischemic Stroke: a Systematic Review with Meta-analysis. Molecular Neurobiology 2025; 62(11) doi: 10.1007/s12035-025-05025-x
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| 18 |
Fatemehsadat Seyedaghamiri, Leila Salimi, Dara Ghaznavi, Emel Sokullu, Reza Rahbarghazi. Exosomes-based therapy of stroke, an emerging approach toward recovery. Cell Communication and Signaling 2022; 20(1) doi: 10.1186/s12964-022-00919-y
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| 19 |
Teng Wan, Yunling Huang, Xiaoyu Gao, Wanpeng Wu, Weiming Guo. Microglia Polarization: A Novel Target of Exosome for Stroke Treatment. Frontiers in Cell and Developmental Biology 2022; 10 doi: 10.3389/fcell.2022.842320
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| 20 |
Qinli Zhang, Hua Xu, XiuYan Han, Xu Liu, Xiaoshu Guo, Hong Liu, Changyun Liu. The role of VCAM1 in post-stroke cognitive impairment: Molecular mechanisms and therapeutic potential. Brain Research Bulletin 2025; 232 doi: 10.1016/j.brainresbull.2025.111584
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| 21 |
Jingfang Lin, Bingjun Zhang, Huiming Xu, Xinghua Zhong, Xuejia Li, Yanna Song, Xi Wang, Yu Peng, Haotian Wu, Haijia Chen, Jiaohua Jiang, Qiyi Chen, Yuanyuan Wang, Changyong Tang, Honghao Wang. HBEGF/EGFR pathway activation by hUC-MSCs improves cognitive outcomes in anti-NMDAR encephalitis. Molecular Therapy 2026; 34(2) doi: 10.1016/j.ymthe.2025.10.040
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| 22 |
Wei Wei, Yongli Pan, Xinyu Yang, Zhonglun Chen, Yue Heng, Bufan Yang, Mingjun Pu, Jiacai Zuo, Zhuhong Lai, Yufeng Tang, Wenqiang Xin. The Emerging Role of the Interaction of Extracellular Vesicle and Autophagy—Novel Insights into Neurological Disorders. Journal of Inflammation Research 2022; doi: 10.2147/JIR.S362865
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| 23 |
Zhibing Song, Xinyu Li, Mengting Lv, Yuchen Guo, Shanshan Deng, Yuefan Zhang, Tiejun Li. Cyclo (MQCNS) has the potential to treat ischemic stroke. Neural Regeneration Research 2023; 18(11) doi: 10.4103/1673-5374.371367
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| 24 |
Heng Zhou, Yan He, Wei Xiong, Shuili Jing, Xingxiang Duan, Zhiyun Huang, Gurek S. Nahal, Youjian Peng, Mingchang Li, Yaoqi Zhu, Qingsong Ye. MSC based gene delivery methods and strategies improve the therapeutic efficacy of neurological diseases. Bioactive Materials 2023; 23 doi: 10.1016/j.bioactmat.2022.11.007
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| 25 |
Chen Wang, Bernd Giebel, Dirk M. Hermann. Neuroprotective and neurorestorative actions of mesenchymal stromal cell-derived small extracellular vesicles in the ischemic brain. Exploration of Neuroscience 2022; doi: 10.37349/en.2022.00005
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| 26 |
Shuang-Yin Lei, Yu-Qian Yang, Jia-Cheng Liu, Dian-Hui Zhang, Yang Qu, Ying-Ying Sun, Hong-Jing Zhu, Sheng-Yu Zhou, Yi Yang, Zhen-Ni Guo. Nanodrug delivery systems for regulating microglial polarization in ischemic stroke treatment: A review. Journal of Tissue Engineering 2024; 15 doi: 10.1177/20417314241237052
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| 27 |
Pengtao Li, Rui Yin, Yihao Chen, Jianbo Chang, Lang Yang, Xiaoyu Liu, Houshi Xu, Xiao Zhang, Shihua Wang, Qin Han, Junji Wei. Engineered extracellular vesicles for ischemic stroke: a systematic review and meta-analysis of preclinical studies. Journal of Nanobiotechnology 2023; 21(1) doi: 10.1186/s12951-023-02114-8
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| 28 |
Endong Zhang, Philana Phan, Zongmin Zhao. Cellular nanovesicles for therapeutic immunomodulation: A perspective on engineering strategies and new advances. Acta Pharmaceutica Sinica B 2023; 13(5) doi: 10.1016/j.apsb.2022.08.020
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| 29 |
Huixia Geng, Luna Chen, Jing Tang, Yi’ang Chen, Lai Wang. The Role of CCL2/CCR2 Axis in Cerebral Ischemia-Reperfusion Injury and Treatment: From Animal Experiments to Clinical Trials. International Journal of Molecular Sciences 2022; 23(7) doi: 10.3390/ijms23073485
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| 30 |
Raed Obaid Saleh, Ali A. Majeed, Ria Margiana, Ola Kamal A. Alkadir, Sami G. Almalki, Pallavi Ghildiyal, Vadim Samusenkov, Noura Kareem Jabber, Yasser Fakri Mustafa, Ahmed Elawady. Therapeutic gene delivery by mesenchymal stem cell for brain ischemia damage: Focus on molecular mechanisms in ischemic stroke. Cell Biochemistry and Function 2024; 42(2) doi: 10.1002/cbf.3957
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| 31 |
Yuqian Xiao, Yanjie Bai, Kexin Sun, Jun Wan, Limin Chen, Shuying Chen, Yan Wang, Wenjing Li, An Liu. Electroacupuncture Improves Learning and Memory Impairment in Rats with Cerebral Ischemia/Reperfusion Injury by Promoting Microglia/Macrophage M2 Polarization Through Nrf2/HO-1 Pathway. Journal of Inflammation Research 2025; doi: 10.2147/JIR.S504670
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| 32 |
Solmaz Fallahi, Hamid Soltani Zangbar, Fereshteh Farajdokht, Reza Rahbarghazi, Gisou Mohaddes, Fariba Ghiasi. Exosomes as a therapeutic tool to promote neurorestoration and cognitive function in neurological conditions: Achieve two ends with a single effort. CNS Neuroscience & Therapeutics 2024; 30(5) doi: 10.1111/cns.14752
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| 33 |
Jiangmei Wang, Jie Xia, Ruoqiong Huang, Yaoqin Hu, Jiajie Fan, Qiang Shu, Jianguo Xu. Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization. Stem Cell Research & Therapy 2020; 11(1) doi: 10.1186/s13287-020-01937-8
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| 34 |
Leyla Norouzi-Barough, Amir Asgari Khosroshahi, Ali Gorji, Fariba Zafari, Mohammad Shahverdi Shahraki, Sadegh Shirian. COVID-19-Induced Stroke and the Potential of Using Mesenchymal Stem Cells-Derived Extracellular Vesicles in the Regulation of Neuroinflammation. Cellular and Molecular Neurobiology 2023; 43(1) doi: 10.1007/s10571-021-01169-1
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| 35 |
Li Li, Rongwen Li, Alex Zacharek, Fengjie Wang, Julie Landschoot-Ward, Michael Chopp, Jieli Chen, Xu Cui. ABCA1/ApoE/HDL Signaling Pathway Facilitates Myelination and Oligodendrogenesis after Stroke. International Journal of Molecular Sciences 2020; 21(12) doi: 10.3390/ijms21124369
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| 36 |
Tianxiang Zeng, Jun Liu, Wenjun Zhang, Yanyan Yu, Xinyun Ye, Qianliang Huang, Peng Li, Qiuhua Jiang. Update on the mechanism of microglia involvement in post-stroke cognitive impairment. Frontiers in Aging Neuroscience 2024; 16 doi: 10.3389/fnagi.2024.1366710
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| 37 |
Katarzyna Curzytek, Monika Leśkiewicz. Targeting the CCL2-CCR2 axis in depressive disorders. Pharmacological Reports 2021; 73(4) doi: 10.1007/s43440-021-00280-w
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| 38 |
Tao Ye, Xinhuang Lv, Qiyao Li, Xiaolan Liao, Lu Zhan, Conghui Dai, Kun Xiang, Xiaoou Lin, Jing Sun, Jiaming Liu. Gut microbial metabolite indole-3-acetic acid inhibits microglia-mediated synaptic loss in Alzheimer’s disease by targeting CCR4. Brain, Behavior, and Immunity 2026; 136 doi: 10.1016/j.bbi.2026.106769
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| 39 |
Fangyan Wang, Jiayin Feng, Anqi Jin, Yunyuan Shao, Mengen Shen, Jiaqi Ma, Lanjie Lei, Liangle Liu. Extracellular Vesicles for Disease Treatment. International Journal of Nanomedicine 2025; doi: 10.2147/IJN.S506456
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| 40 |
Hua Wang, Xiaohui Li, Ziyu Liu, Ruirui Lu, Xiaopeng Li, Xiaoguang Zhang. ANXA1 regulates microglia polarization and autophagy via PI3K/Akt/mTOR pathway to reduce inflammatory injury after cerebral ischemia-reperfusion. Cellular Signalling 2026; 139 doi: 10.1016/j.cellsig.2025.112336
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| 41 |
Lv Geng, Xiaoya Xu, Xinyue Lei, Xiaoju Zhou. Transdermal delivery of engineered exosomes for diabetic wound healing: Driving M2 macrophage polarization. Chinese Chemical Letters 2026; doi: 10.1016/j.cclet.2026.113079
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| 42 |
Masako Nakano, Mineko Fujimiya. Potential effects of mesenchymal stem cell derived extracellular vesicles and exosomal miRNAs in neurological disorders. Neural Regeneration Research 2021; 16(12) doi: 10.4103/1673-5374.313026
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| 43 |
Junxuan Lyu, Di Xie, Tarun N. Bhatia, Rehana K. Leak, Xiaoming Hu, Xiaoyan Jiang. Microglial/Macrophage polarization and function in brain injury and repair after stroke. CNS Neuroscience & Therapeutics 2021; 27(5) doi: 10.1111/cns.13620
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| 44 |
Linli Li, Peipei Wu, Hui Qian, Wenrong Xu, Hui Shi, Jiajia Jiang, G. Krishnamurithy. Tailored Extracellular Vesicles: Novel Tool for Tissue Regeneration. Stem Cells International 2022; 2022 doi: 10.1155/2022/7695078
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| 45 |
Muhammad Azhar Ud Din, Aijun Wan, Ying Chu, Jing Zhou, Yongmin Yan, Zhiliang Xu. Therapeutic role of extracellular vesicles from human umbilical cord mesenchymal stem cells and their wide therapeutic implications in inflammatory bowel disease and other inflammatory disorder. Frontiers in Medicine 2024; 11 doi: 10.3389/fmed.2024.1406547
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| 46 |
Morteza Jafarinia, Majid Reza Farrokhi, Mazdak Ganjalikhani Hakemi, William C. Cho. The role of miRNAs from mesenchymal stem/stromal cells-derived extracellular vesicles in neurological disorders. Human Cell 2022; 36(1) doi: 10.1007/s13577-022-00813-2
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| 47 |
Jingjing Li, Lijuan Zhang, Sujun Xue, Chao Yu, Yumeng Li, Shuangping Li, Qingping Ye, Xianchun Duan, Daiyin Peng. Exploration of the mechanism of Taohong Siwu Decoction for the treatment of ischemic stroke based on CCL2/CCR2 axis. Frontiers in Pharmacology 2024; 15 doi: 10.3389/fphar.2024.1428572
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| 48 |
Matthew J. Krinock, Neel S. Singhal. Diabetes, stroke, and neuroresilience: looking beyond hyperglycemia. Annals of the New York Academy of Sciences 2021; 1495(1) doi: 10.1111/nyas.14583
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| 49 |
Rui Dong, Renxuan Huang, Jiaoqi Wang, Hongyu Liu, Zhongxin Xu. Effects of Microglial Activation and Polarization on Brain Injury After Stroke. Frontiers in Neurology 2021; 12 doi: 10.3389/fneur.2021.620948
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