Dual cut-offs and beyond: Expanding the role of transient elastography in primary biliary cholangitis

Table 1 Diagnostic accuracy of vibration-controlled transient elastography for advanced fibrosis/cirrhosis vs liver histology

Ref.	Reported AUROC/Sens/spec	Cut-offs (kPa)
Cristoferi et al[10]	AUROC: AF: 0.89	AF > 11.0
Osman et al[39]	AUROC: F4: 0.94	F4: 14.4
Zhang et al[37]	AUROC: F4: 0.90	F4: 13.2
Chen et al[4]1	AUROC: SF: 0.93; AF: 0.93; F4: 0.91	AF: 9.6-10.7; F4: 14.4-16.9
Manzo-Francisco et al[22]1	Sens/spec: F3: 68%/92%; F4: 90%/94%; AUROC: F3: 0.91; F4: 0.97	Mean cut-off: F3: 9.28; F4: 15.2
An et al[5]1	AUROC: SF: 0.87; AF: 0.89; cirrhosis: 0.99	AF: 7.5-17.9; cirrhosis: 11.4-25.1
Marcos Carrasco et al[6]1	Sens/spec: ≥ F2: 0.76/0.93; ≥ F3: 0.88/0.90; = F4: 0.91/0.95	NA

¹Meta-analysis.

Sens: Sensitivity; Spec: Specificity; AUROC: Area under the receiver operating characteristic curve; AF: Advanced fibrosis; SF: Significant fibrosis; NA: Not applicable.