©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 28, 2026; 32(8): 115416
Published online Feb 28, 2026. doi: 10.3748/wjg.v32.i8.115416
Published online Feb 28, 2026. doi: 10.3748/wjg.v32.i8.115416
Dual cut-offs and beyond: Expanding the role of transient elastography in primary biliary cholangitis
Vasily Isakov, Alexei Goncharov, Department of Gastroenterology and Hepatology, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow 115446, Russia
Author contributions: Isakov V and Goncharov A contributed to this paper; Isakov V designed the overall concept and outline of the manuscript; Goncharov A contributed to the discussion of the manuscript; Isakov V and Goncharov A contributed to the writing, and editing the manuscript, and review of literature.
Supported by the Ministry of Science and Higher Education of the Russian Federation, No. FGMF-2025-0003.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Corresponding author: Vasily Isakov, PhD, Professor, Department of Gastroenterology and Hepatology, Federal Research Center of Nutrition, Biotechnology and Food Safety, 21 Kashirskoe Shosse, Moscow 115446, Russia. vasily.isakov@gmail.com
Received: October 16, 2025
Revised: November 30, 2025
Accepted: January 7, 2026
Published online: February 28, 2026
Processing time: 118 Days and 12.7 Hours
Revised: November 30, 2025
Accepted: January 7, 2026
Published online: February 28, 2026
Processing time: 118 Days and 12.7 Hours
Core Tip
Core Tip: Transient elastography is transforming the fibrosis evaluation in primary biliary cholangitis (PBC). The dual cut-offs proposed by Chen et al (≤ 10 kPa and > 14.5 kPa) achieved excellent diagnostic accuracy and could eliminate the need for biopsy in most patients. However, interpretation requires attention to confounders such as cholestasis, inflammation, and overlap syndromes. Standardized protocols, cross-modality validation, and integration with clinical scores will define the next frontier of precision staging for PBC.