Plasma proteomic profiling of gastric cancer: Super minimally invasive surgery vs organ-resection on trauma immunity

Table 1 Comparison of general data of gastric cancer patients in two groups, n (%)/median (interquartile range)/mean ± SD

Variables	SMIS (n = 20)	ORS (n = 18)	P value
Gender			0.164
Male	18 (90)	13 (72)
Female	2 (10)	5 (28)
Age (years)	61 (55.5, 72)	60.5 (46.5 65)	0.219
BMI (kg/m2)	24.95 (23.6, 27.25)	22.95 (21.15, 26.05)	0.106
Smoking history	7 (35)	7 (39)	1.000
History of alcohol use	10 (50)	9 (50)	1.000
History of Helicobacter pylori infection	3 (15)	3 (17)	1.000
Hypertension	10 (50)	6 (33)	0.342
Diabetes	5 (25)	4 (22)	1.000
Coronary heart disease, pre-operative blood test	4 (20)	1 (6)	0.344
White blood cells (× 109/L)	6.085 (5.515, 7.57)	5.57 (4.385, 7.185)	0.148
Neutrophils (× 109/L)	0.558 ± 0.721	0.608 ± 0.949	0.076
Lymphocytes (× 109/L)	0.335 ± 0.729	0.293 ± 0.853	0.12
Monocytes (× 109/L)	0.0775 (0.065, 0.088)	0.074 (0.057, 0.082)	0.342
Previous medication history			1.000
Anti-inflammatory drugs (anticoagulants, anti-platelet drugs, non-steroidal anti-inflammatory drugs, hormonal drugs)	2 (10)	1 (5.6)
No anti-inflammatory medication	18 (90)	17 (94.4)

SMIS: Super minimally invasive surgery; ORS: Organ-resection surgery; BMI: Body mass index.

Table 2 Comparison of clinical characteristics and treatment options data, n (%)/median (interquartile range)

	SMIS (n = 20)	ORS (n = 18)	P value
Tumor pathology type			< 0.001
Severe atypical hyperplasia (high-grade intraepithelial neoplasia)	4 (20)	0
High-grade intraepithelial neoplasia with carcinoma	9 (45)	0
Moderately differentiated adenocarcinoma	3 (15)	0
Poorly differentiated adenocarcinoma	0	6 (33.3)
Low and intermediate grade glandular cancer	2 (10)	3 (16.7)
Signet ring cell carcinoma	1 (5)	0
Low-to-moderately differentiated adenocarcinoma combined with signet ring cell carcinoma	0	4 (20)
Undifferentiated adenocarcinoma combined with signet ring cell carcinoma	1 (5)	5 (25)
Number of types of antibiotics used			0.03829
Use of 1 antibiotic	9 (45)	2 (11)
Use of 2 antibiotics	4 (20)	7 (39)
Use of 3 antibiotics	5 (25)	9 (50)
Use of 4 antibiotics	0	0
No antibiotics used	2 (10)	0
Duration of antibiotic use	2 (2, 3)	6 (5.5, 7)	< 0.001
Postoperative analgesia			< 0.001
Yes	2 (10)	17 (94.4)
No	18 (90)	1 (5.6)
Length of stay after surgery	5 (5, 7)	7 (6, 7.5)	0.002849
Hospitalization costs	24710.9 (20873.79, 31738.355)	93442.45 (84969.0, 101357.365)	< 0.001
Postoperative temperature			0.01544
Low-grade fever (37.3-38.0 °C)	1 (5)	7 (38.9)
Medium fever (38.1-39.0 °C)	2 (10)	1 (5.6)
High fever (> 39.1 °C)	0	1 (5.6)
Normal temperature	17 (85)	9 (50)

SMIS: Super minimally invasive surgery; ORS: Organ-resection surgery.