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World J Gastroenterol. Apr 28, 2026; 32(16): 117799
Published online Apr 28, 2026. doi: 10.3748/wjg.v32.i16.117799
Published online Apr 28, 2026. doi: 10.3748/wjg.v32.i16.117799
Plasma proteomic profiling of gastric cancer: Super minimally invasive surgery vs organ-resection on trauma immunity
Yao-Qian Yuan, Qian-Qian Chen, Pan Xiao, Hui-Kai Li, Kun-Ming Lv, Shuai Tian, Jing Hao, En-Qiang Linghu, Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Kun-Ming Lv, Hui Shi, Department of Gastroenterology, The Second Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Yang Yan, Department of General Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
Co-first authors: Yao-Qian Yuan and Qian-Qian Chen.
Co-corresponding authors: Yang Yan and En-Qiang Linghu.
Author contributions: Yuan YQ and Chen QQ made equal contributions as co-first authors; Linghu EQ and Chen QQ contributed to conceptualization and supervision; Yuan YQ and Xiao P contributed to experiments; Yuan YQ, Li HK, Lv KM, Tian S, Shi H, and Hao J contributed to data collection and analysis; Yan Y contributed to literature review; Yuan YQ contributed to writing draft; Linghu EQ, Chen QQ, Li HK, Yan Y, Shi H, and Hao J contributed to surgical procedures; Linghu EQ and Yan Y made equal contributions as co-corresponding authors. All authors approved the final format of the submitted manuscript.
Supported by National Key Research and Development Program of China, No. 2022YFC2503601.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the Chinese PLA General Hospital, No. S2023-188-01.
Clinical trial registration statement: This study is registered at Chinese Clinical Trial Registry, No. ChiCTR2500097111.
Informed consent statement: Written informed consent was obtained from all individual participants included in the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Corresponding author: En-Qiang Linghu, MD, Chief Physician, Professor, Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China. linghuenqiang@vip.sina.com
Received: December 16, 2025
Revised: January 18, 2026
Accepted: February 12, 2026
Published online: April 28, 2026
Processing time: 121 Days and 18.1 Hours
Revised: January 18, 2026
Accepted: February 12, 2026
Published online: April 28, 2026
Processing time: 121 Days and 18.1 Hours
Core Tip
Core Tip: The optimal extent of surgical intervention for gastric cancer remains controversial, particularly with respect to its impact on postoperative immune homeostasis. This study integrates super minimally invasive surgery concepts with proteomic profiling to investigate immune-inflammatory alterations following different surgical strategies, providing mechanistic insights that may support more individualized, trauma-conscious surgical decision-making in early gastric cancer.