Complete blood counts and their derived inflammatory markers with anal fistulas in male children: A retrospective case-control study

Table 1 Baseline characteristics and comparisons of complete blood count and inflammatory biomarkers between the control and pediatric fistula-in-ano groups

Variable	Total (n = 974)	Control (n = 293)	Case (n = 681)	P value	Z value
Age (months), median IQR	12.0 (9.0-31.0)	16.0 (12.0-48.0)	11.0 (8.0-12.0)	< 0.001	-19.484
WBC (× 109/L), median IQR	8.3 (6.4-11.0)	6.0 (4.8-7.0)	9.8 (7.8-12.1)	< 0.001	5.711
NEUT (× 109/L), median IQR	2.7 (1.9-3.6)	3.0 (2.2-4.1)	2.5 (1.9-3.3)	< 0.001	-23.839
LYMPH (× 109/L), median IQR	4.9 (2.7-7.2)	2.1 (1.5-2.6)	6.2 (4.7-8.1)	< 0.001	-2.658
MONO (× 109/L), median IQR	0.5 (0.4-0.6)	0.5 (0.4-0.6)	0.5 (0.4-0.6)	0.008	-17.460
EO (× 109/L), median IQR	0.2 (0.1-0.3)	0.1 (0.0-0.1)	0.2 (0.2-0.4)	< 0.001	-16.209
BASO (× 109/L), median IQR	0.0 (0.0-0.0)	0.0 (0.0-0.0)	0.0 (0.0-0.0)	< 0.001	21.915
NLR, median IQR	0.5 (0.3-1.1)	1.5 (1.0-2.2)	0.4 (0.3-0.6)	< 0.001	16.291
PLR, median IQR	66.5 (46.7-90.8)	95.5 (74.9-122.0)	55.9 (40.5-75.1)	< 0.001	22.783
MLR, median IQR	0.1 (0.1-0.2)	0.2 (0.2-0.3)	0.1 (0.1-0.1)	< 0.001	15.205
SII, median IQR	169.8 (104.9-267.0)	279.4 (192.2-436.4)	137.4 (88.7-198.6)	< 0.001	19.255
SIRI, median IQR	0.3 (0.2-0.6)	0.7 (0.4-1.1)	0.2 (0.1-0.3)	< 0.001	18.273

IQR: Interquartile range; WBC: White blood cell; NEUT: Neutrophil; LYMPH: Lymphocyte; MONO: Monocyte; EO: Eosinophil; BASO: Basophil; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; MLR: Monocyte-to-lymphocyte ratio; SII: Systemic immune-inflammation index; SIRI: Systemic inflammatory response index.

Table 2 Logistic analysis of pediatric fistula-in-ano and complete blood count-derived inflammatory indicators

Variable	Crude OR (95%CI)	Crude P value	Adjusted OR (95%CI)	Adjusted P value
WBC (× 109/L)	2.31 (2.06-2.60)	< 0.001	2.18 (1.94-2.47)	< 0.001
NEUT (× 109/L)	0.86 (0.78-0.93)	0.001	1.03 (0.93-1.15)	0.577
LYMPH (× 109/L)	15.90 (10.32-26.41)	< 0.001	17.78 (11.24-30.34)	< 0.001
MONO (× 109/L)	3.34 (1.60-7.32)	0.002	1.04 (0.60-2.14)	0.899
EO (× 109/L)	1.13 (1.11-1.15)	< 0.001	1.11 (1.09-1.13)	< 0.001
BASO (× 109/L)	2.46 (2.16-2.83)	< 0.001	2.52 (2.17-2.94)	< 0.001
NLR	0.04 (0.03-0.06)	< 0.001	0.05 (0.03-0.09)	< 0.001
PLR	0.96 (0.96-0.97)	< 0.001	0.97 (0.97-0.98)	< 0.001
MLR	0.77 (0.76-0.80)	< 0.001	0.80 (0.77-0.82)	< 0.001
SII	0.62 (0.57-0.68)	< 0.001	0.78 (0.70-0.86)	< 0.001
SIRI	0.03 (0.01-0.04)	< 0.001	0.05 (0.03-0.08)	< 0.001

Data for monocyte-to-lymphocyte ratio, systemic immune-inflammation index, eosinophil, and basophil were multiplied by 100 for analysis. OR: Odds ratio; CI: Confidence interval; WBC: White blood cell; NEUT: Neutrophil; LYMPH: Lymphocyte; MONO: Monocyte; EO: Eosinophil; BASO: Basophil; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; MLR: Monocyte-to-lymphocyte ratio; SII: Systemic immune-inflammation index; SIRI: Systemic inflammatory response index.