Ma HF, Chen YH, Wang Y, Zhang XC, Li JN, Wang YM, Zhou ZY. Complete blood counts and their derived inflammatory markers with anal fistulas in male children: A retrospective case-control study. World J Gastroenterol 2025; 31(45): 112926 [DOI: 10.3748/wjg.v31.i45.112926]
Corresponding Author of This Article
Huang-Fu Ma, MD, Doctor, Department of Proctology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. mahuangfu@zryhyy.com.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Dec 7, 2025 (publication date) through Dec 6, 2025
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Journal Information of This Article
Publication Name
World Journal of Gastroenterology
ISSN
1007-9327
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Ma HF, Chen YH, Wang Y, Zhang XC, Li JN, Wang YM, Zhou ZY. Complete blood counts and their derived inflammatory markers with anal fistulas in male children: A retrospective case-control study. World J Gastroenterol 2025; 31(45): 112926 [DOI: 10.3748/wjg.v31.i45.112926]
Huang-Fu Ma, Yue Wang, Xue-Cheng Zhang, Jia-Nan Li, Yan-Mei Wang, Department of Proctology, China-Japan Friendship Hospital, Beijing 100029, China
Yi-Hao Chen, The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Zhang-Yun Zhou, Department of Gastrointestinal Surgery, Anhui Zhongke Gengjiu Hospital, Hefei 230051, Anhui Province, China
Co-first authors: Huang-Fu Ma and Yi-Hao Chen.
Author contributions: Ma HF and Chen YH drafted the manuscript, they contributed equally to this work; Zhang XC and Wang Y performed the statistical analyses and created the figures; Li JN, Zhou ZY, and Wang YM contributed to the manuscript review; Ma H and Wang Y conceived the study and contributed to the manuscript review; all the authors have read and approved the final version of the manuscript.
Supported by the China-Japan Friendship Hospital Scientific Research Fund, No. 2024-ZF-31 and No. 2024-ZF-12.
Institutional review board statement: The study protocol was approved by the ethics committee of China-Japan Friendship Hospital (approval No. 2024-KY-387).
Informed consent statement: All data used in this study were utilized under a waiver of informed consent, and no separate informed consent was obtained from the parents or legal guardians of minors.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Data sharing statement: Data supporting the findings of this study are available from the corresponding author upon request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Huang-Fu Ma, MD, Doctor, Department of Proctology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. mahuangfu@zryhyy.com.cn
Received: August 11, 2025 Revised: September 3, 2025 Accepted: October 22, 2025 Published online: December 7, 2025 Processing time: 116 Days and 1.2 Hours
Core Tip
Core Tip: This retrospective case-control study analyzed 974 male infants and toddlers, including 681 with pediatric fistula-in-ano (PFIA) and 293 healthy controls, to assess the relationship between complete blood count-derived inflammatory markers and PFIA. Patients showed higher lymphocyte counts but lower monocyte-to-lymphocyte ratio (MLR) and systemic inflammatory response index (SIRI) levels, which remained significant after age adjustment. Lymphocyte count, MLR, and SIRI demonstrated strong predictive value and clinical utility for PFIA detection and prognosis. The number of fistula tracts correlated with these markers. Lymphocyte count may serve as a useful biomarker, supporting early diagnosis and targeted prevention in pediatric PFIA.
