Repeat ablation and single-session ablation in patients with multiple colorectal cancer liver metastases after chemotherapy failure

Table 1 Characteristics of patients in single-session and repeat ablation

Variables	Single	Repeat	P value
No. of patient	42	38
Age	58.69 ± 12.2	59.39 ± 8.45	0.977
Size (max, cm)	1.9 (1.1)	1.8 (1.0)	0.958
Sex			0.954
Male	28	25
Female	14	13
Quantity	2 (1)	3 (2)	0.000a
Time	1	2 (1)	0.000a
Primary lesion			0.287
Colon	16	19
Rectum	26	19
Pathological differentiation			0.557
Medium-high	34	34
Poorly	6	4
Hepatectomy	5	12	0.002
Extrahepatic metastases
Regional	22	9	0.000a
Distant	4	1	0.000a

^aP < 0.05.

Table 2 Association between lesion characteristics and overall survival-univariate analysis

Variables	Totally		Single		Repeat
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Sex	2.1 (0.45-10)	0.340	2.6 (0.31-23)	0.380	1.6 (0.16-15)	0.7
Age	1.1 (1-1.2)	0.029a	1.1 (1-1.2)	0.065	1.1 (0.93-1.3)	0.3
Size (max, cm)	3.0 (1.7-5.4)	0.000a	2 (0.66-5.8)	0.231	6.4 (1.4-29)	0.017a
Quantity	NA	NA	2 (0.78-5.1)	0.151	1 (0.66-1.6)	0.87
Time	0.78 (0.22-2.8)	0.69	NA	NA	1.1 (0.32-3.9)	0.87
Colon/rectum	0.13 (0.02-1)	0.052	0.29 (0.03-2.5)	0.260	0.10 (0.00-2.7)1	0.045a
Pathological differentiation	0.73 (0.15-3.4)	0.690	0.51 (0.09-2.8)	0.440	0.94 (0.04-24.8)1	0.97
Hepatectomy2	0.21 (0.01-4.2)2	0.17	0.57 (0.03-12.8)2	0.678	0.21 (0.01-5.54)1	0.203
Recurrence	11 (1.5-91)	0.021a	5.7 (0.66-49)	0.110	12.6 (0.48-332.8)1	0.022a
Extrahepatic metastases
Regional	2.5 (0.7-8.8)	0.16	2 (0.36-11)	0.43	3 (0.43-22)	0.27
Distant2	7.86 (2.06-29.9)2	0.007a	5.83 (1.09-31.1)2	0.048a	20.7 (2.0-215)2	0.018a

¹Hazard ratio: Extreme hazard ratio values adjusted via Firth regression.

²Hazard ratio: Small sample sizes adjusted via Firth regression.

^aP < 0.05.

NA: Not available; HR: Hazard ratio; CI: Confidence interval.

Table 3 Association between lesion characteristics and progression-free survival-univariate analysis

Variables	Totally		Single		Repeat
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Sex	1.3 (0.64-2.6)	0.35	1.4 (0.55-3.7)	0.47	1.1 (0.39-3.3)	0.81
Age	1 (0.97-1)	0.92	1 (0.96-1)	0.89	1 (0.95-1.1)	0.62
Size (max, cm)	2.2 (1.5-3.1)	0.000a	1.7 (1-3)	0.05a	3.8 (1.9-8)	0.000a
Quantity	NA	NA	1.5 (0.88-2.7)	0.13	1.2 (1.0-1.5)	0.041a
Time	1.1 (0.78-1.6)	0.52	NA	NA	1.8 (0.98-0.31)	0.047a
Colon/rectum	0.52 (0.26-1.0)	0.062	0.54 (0.21-1.4)	0.21	0.51 (0.19-1.4)	0.2
Pathological differentiation	0.89 (0.37-2.1)	0.80	1.2 (0.4-3.6)	0.76	0.37 (0.079-1.7)	0.21
Hepatectomy1	20.51 (0.20-1.27)1	0.11	0.77 (0.20-2.97)1	0.69	0.41 (0.12-1.40)1	0.114
Extrahepatic metastases
Regional	1.3 (0.68-2.5)	0.41	1.6 (0.64-3.9)	0.33	0.91 (0.29-2.8)	0.87
Distant1	4.39 (1.73-11.15)1	0.007a	4.29 (1.4-12.74)1	0.019a	5.77(0.93-36.0)1	0.106

¹Hazard ratio: Small sample sizes adjusted via Firth regression.

^aP < 0.05.

NA: Not available; HR: Hazard ratio; CI: Confidence interval.