Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2025; 31(43): 111494
Published online Nov 21, 2025. doi: 10.3748/wjg.v31.i43.111494
Published online Nov 21, 2025. doi: 10.3748/wjg.v31.i43.111494
Repeat ablation and single-session ablation in patients with multiple colorectal cancer liver metastases after chemotherapy failure
Si-Qi Gao, Qi-Yu Zhao, Tian-An Jiang, Department of Ultrasound, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Bo-Wen Zhang, Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Co-first authors: Si-Qi Gao and Bo-Wen Zhang.
Author contributions: Gao SQ and Zhang BW conducted the formal analysis and investigation, made equal contributions as co-first authors; Jiang TA contributed to conceptualization and acquired funding; Jiang TA and Zhao QY developed the methodology; Gao SQ prepared the original draft; Zhang BW undertaken review and editing; all authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 82027803 and No. 81971623; and Key Research and Development Project of Zhejiang Province, No. 2024C03092.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of The First Affiliated Hospital, Zhejiang University School of Medicine, No. IIT20241080A.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to biopsy and treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets generated during the current study are available from the first author and corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tian-An Jiang, Professor, Senior Researcher, Department of Ultrasound, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. tiananjiang@zju.edu.cn
Received: July 2, 2025
Revised: August 24, 2025
Accepted: October 21, 2025
Published online: November 21, 2025
Processing time: 141 Days and 17.1 Hours
Revised: August 24, 2025
Accepted: October 21, 2025
Published online: November 21, 2025
Processing time: 141 Days and 17.1 Hours
Core Tip
Core Tip: This is a retrospective study to investigate long-term survival and factors affecting outcomes of radiofrequency ablation in patients with multiple refractory colorectal liver metastases after systemic chemotherapy failure. No significant differences emerged in overall survival or progression-free survival when comparing single-session with repeat ablation. Nevertheless, supplemental or additional ablation sessions appeared to improve the likelihood of patients attaining a tumor-free status, suggesting a potential benefit in refractory colorectal liver metastases.