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©The Author(s) 2023.
World J Gastroenterol. Apr 7, 2023; 29(13): 2034-2049
Published online Apr 7, 2023. doi: 10.3748/wjg.v29.i13.2034
Published online Apr 7, 2023. doi: 10.3748/wjg.v29.i13.2034
Table 1 Comparison of the general information among the three groups of individuals
Indicator | TEN (n = 10) | TPN (n = 10) | SPN (n = 10) | H/F/χ2/Z/t value | P value |
Age (yr, mean ± SD) | 59.20 ± 12.52 | 54.30 ± 15.10 | 59.30 ± 16.33 | 0.46 | 0.63 |
Sex | |||||
Male (case, %) | 8 (80) | 8 (80) | 8 (80) | 0.00 | 1.00 |
Female (case, %) | 2 (20) | 2 (20) | 2 (20) | ||
Underlying disease | |||||
Hypertension (case, %) | 4 (40) | 3 (30) | 5 (50) | 0.83 | 0.65 |
Diabetes (case, %) | 2 (20) | 4 (40) | 2 (20) | 1.36 | 0.50 |
Malignant tumor (case, %) | 0 (0) | 2 (20) | 2 (20) | 2.30 | 0.31 |
APACHE II score on day 1 (points, mean ± SD) | 14.10 ± 2.84 | 15.30 ± 4.73 | 19.50 ± 7.38 | 2.12 | 0.14 |
SOFA score on day 1 (points, mean ± SD) | 5.40 ± 1.51 | 9.60 ± 1.95 | 10.20 ± 4.10 | 5.53 | 0.10 |
BMI (kg/m2, mean ± SD) | 23.90 ± 2.79 | 26.84 ± 3.89 | 26.05 ± 2.67 | 1.90 | 0.17 |
NUTRIC score on day 1 | |||||
≥ 6 points (case, %) | 3 (30) | 6 (60) | 6 (60) | 2.40 | 0.30 |
< 6 points (case, %) | 7 (70) | 4 (40) | 4 (40) | ||
REE on day 1 [kcal, M (P25, P75)] | 1950.00 (1759.28, 2050.72) | 1900 (1726.40, 2073.59) | 2036 (1882.46, 2189.53) | 2.49 | 0.28 |
Table 2 Effect of different nutritional modalities on immune and nutritional indicators in patients with sepsis
Indicator | TEN (n = 20) | SPN (n = 20) | TPN (n = 20) | |||||||||
Day 1 (n = 10) | Day 5 (n = 10) | t/Z value | P value | Day 1 (n = 10) | Day 5 (n = 10) | t/Z value | P value | Day 1 (n = 10) | Day 5 (n = 10) | t/Z value | P value | |
CD3+ T cell [%, M (P25, P75)] | 69.85 (63.62, 78.77) | 77.77 (69.40, 80.48) | 2.09 | 0.03 | 71.33 (64.42, 76.50) | 72.25 (64.59, 82.59) | 1.78 | 0.07 | 74.21 (59.82, 83.43) | 74.80 (67.23, 82.74) | 0.76 | 0.44 |
CD3+ CD4+ T cell [%, M (P25, P75)] | 36.40 (29.47, 43.39) | 40.39 (36.96, 46.50) | 1.98 | 0.04 | 38.21 (32.22, 57.15) | 47.37 (35.61, 58.27) | 1.17 | 0.24 | 38.12 (29.23, 46.40) | 45.67 (28.13, 51.69) | 1.37 | 0.16 |
CD19+ B cell [%, M (P25, P75)] | 17.04 (11.55, 21.27) | 14.11 (8.99, 18.03) | 1.98 | 0.04 | 16.80 (10.70, 25.14) | 9.75 (6.47, 16.59) | 2.09 | 0.03 | 14.35 (6.62, 22.89) | 12.78 (6.93, 23.61) | 1.02 | 0.30 |
IgA (g/L mean ± SD) | 2.53 ± 1.18 | 2.93 ± 0.93 | 1.97 | 0.08 | 2.15 ± 0.83 | 2.91 ± 1.19 | 3.87 | 0.00 | 2.10 ± 1.13 | 2.45 ± 0.73 | 1.44 | 0.18 |
IgG (g/L, mean ± SD) | 11.75 ± 3.46 | 15.19 ± 5.84 | 3.10 | 0.01 | 9.05 ± 3.78 | 13.77 ± 4.52 | 5.48 | 0.00 | 9.32 ± 3.89 | 12.15 ± 3.85 | 3.48 | 0.00 |
IgM (g/L, mean ± SD) | 0.81 ± 0.36 | 1.11 ± 0.48 | 1.49 | 0.16 | 0.95 ± 0.44 | 1.12 ± 0.75 | 1.11 | 0.29 | 0.77 ± 3.89 | 0.89 ± 0.46 | 1.02 | 0.33 |
C3 (g/L, mean ± SD) | 0.99 ± 0.30 | 1.21 ± 0.23 | 2.84 | 0.01 | 0.81 ± 0.21 | 1.07 ± 0.23 | 4.73 | 0.00 | 0.77 ± 0.25 | 0.88 ± 0.33 | 0.95 | 0.36 |
C4 (g/L, mean ± SD) | 0.19 ± 0.04 | 0.22 ± 0.05 | 2.08 | 0.06 | 0.19 ± 0.07 | 0.22 ± 0.07 | 3.64 | 0.00 | 0.17 ± 0.05 | 0.21 ± 0.08 | 1.75 | 0.11 |
Albumin (g/L, mean ± SD) | 27.14 ± 3.18 | 29.89 ± 3.61 | 3.04 | 0.01 | 27.74 ± 3.45 | 30.97 ± 2.63a | 2.68 | 0.02 | 28.10 ± 3.37 | 27.73 ± 2.64 | 0.24 | 0.81 |
Pre-albumin (g/L, mean ± SD) | 0.10 ± 0.04 | 0.15 ± 0.07a | 3.88 | 0.00 | 0.08 ± 0.41 | 0.13 ± 0.05 | 3.42 | 0.00 | 0.10 ± 0.03 | 0.11 ± 0.03 | 0.47 | 0.64 |
Transferrin (g/L, mean ± SD) | 0.01 ± 0.28 | 0.01 ± 0.28 | 1.52 | 0.15 | 1.16 ± 0.36 | 1.36 ± 0.51 | 2.67 | 0.02 | 1.05 ± 0.30 | 1.20 ± 0.37 | 1.11 | 0.29 |
- Citation: Yang XJ, Wang XH, Yang MY, Ren HY, Chen H, Zhang XY, Liu QF, Yang G, Yang Y, Yang XJ. Exploring choices of early nutritional support for patients with sepsis based on changes in intestinal microecology. World J Gastroenterol 2023; 29(13): 2034-2049
- URL: https://www.wjgnet.com/1007-9327/full/v29/i13/2034.htm
- DOI: https://dx.doi.org/10.3748/wjg.v29.i13.2034