Randomized Clinical Trial
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2023; 29(13): 2034-2049
Published online Apr 7, 2023. doi: 10.3748/wjg.v29.i13.2034
Exploring choices of early nutritional support for patients with sepsis based on changes in intestinal microecology
Xiao-Juan Yang, Xiao-Hong Wang, Ming-Yue Yang, Hong-Yan Ren, Hui Chen, Xiao-Ya Zhang, Qin-Fu Liu, Ge Yang, Yi Yang, Xiao-Jun Yang
Xiao-Juan Yang, Xiao-Hong Wang, Xiao-Ya Zhang, Qin-Fu Liu, Xiao-Jun Yang, Department of Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China
Xiao-Juan Yang, Ge Yang, School of Clinical Medicine, Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China
Ming-Yue Yang, Department of Emergency Medicine, Affiliated Hospital of Jining Medical University, Jining 272030, Shandong Province, China
Hong-Yan Ren, Hui Chen, Shanghai Mobio Biomedical Technology Co., Ltd., Shanghai 201318, China
Yi Yang, Department of Critical Care Medicine, Southeast University School of Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China
Author contributions: Yang XJ was the guarantor and designed the study; Yang XJ participated in the acquisition, analysis, and interpretation of the data, and drafted the initial manuscript; Yang MY, Zhang XY, Liu QF, Yang G participated in the acquisition and the analysis of data; Wang XH, Ren HY, Chen H, Yang Y, revised the article critically for important intellectual content.
Supported by Ningxia Natural Science Foundation Project, No. 2022AAC03488; and the National Key Research and Development Program of China, No. 2016YFD0400605.
Institutional review board statement: This study was approved by the Ethics Committee of General Hospital of Ningxia Medical University, No. 2017-266.
Clinical trial registration statement: This study is registered at http://www.chictr.org.cn. The registration identification number is ChiCTR2200066641.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: Yang YJ reports grants from Ningxia Natural Science Foundation Project, grants from National Key Research and Development Program of China, during the conduct of the study.
Data sharing statement: Technical appendix, statistical code, and dataset available from the SRA database of NCBI, SRA number: PRJNA861102. Participants consent for data sharing was not obtained but the presented data are anonymized and risk of identification is low. No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Jun Yang, PhD, Chief Physician, Department of Critical Care Medicine, General Hospital of Ningxia Medical University, No. 804 Shengli South Street, Xingqing District, Yinchuan 750004, Ningxia Hui Autonomous Region, China. yxjicu@163.com
Received: December 13, 2022
Peer-review started: December 13, 2022
First decision: January 11, 2023
Revised: January 21, 2023
Accepted: March 20, 2023
Article in press: March 20, 2023
Published online: April 7, 2023
Processing time: 114 Days and 21.2 Hours
Core Tip

Core Tip: Nutritional support is an important component of treatment for sepsis, and an appropriate modality of nutritional support can improve patient nutrition, immunity, and intestinal microecology. We applied different nutritional modalities for early and short-duration nutritional support in patients with sepsis and found differences in intestinal bacterial composition, short-chain fatty acids, and nutritional and immune indicators. We concluded that total enteral nutrition is a good modality of early nutritional support for sepsis. These findings provide a new perspective for optimizing nutritional support modalities in sepsis.