Conditioned secretome of adipose-derived stem cells improves dextran sulfate sodium-induced colitis in mice

doi:10.3748/wjg.v27.i23.3342

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 21, 2021; 27(23): 3342-3356
Published online Jun 21, 2021. doi: 10.3748/wjg.v27.i23.3342

Table 1 Cytokine expression profiles in the secretomes of mouse adipose-derived stem cells and mouse adipose-derived stem cells stimulated with lipopolysaccharides (μg/mL) for 24 h

Cytokine	mADSCs	MADSCs w/LPS	Ratio¹
CCL4	218	4516	20.8
G-CSF	218	4138	19.0
CXCL2	467	4811	10.3
CXCL10	433	4342	10.0
GM-CSF	335	3198	9.5
CCL3	629	4986	7.9
TNF-α	836	5863	7.0
IL-1ra	515	3610	7.0
CXCL1	1583	6263	4.0
CCL1	307	1178	3.8
CCL5	1137	4194	3.7
CD54	243	796	3.3
CXCL9	399	1180	3.0
M-CSF	1530	3147	2.1
IL-6	3197	4642	1.5
IFN-γ	512	559	1.1
CXCL12	4711	4798	1.0
TIMP-1	3735	3553	1.0
CCL2	5228	3646	0.7
IL-1α	852	482	0.6

¹Ratio represents the intensity value of mouse adipose-derived stem cells (mADSCs) w/lipopolysaccharides relative to the intensity value of mADSCs used as a control. mADSCs: Mouse adipose-derived stem cells; LPS: Lipopolysaccharides; CCL: Carbon tetrachloride; G-CSF: Granulocyte colony-stimulating factor; CXCL: (C-X-C motif) ligand; TNF-α: Tumor necrosis factor-α; IL: Interleukin; M-CSF: Macrophage-colony stimulating factor; IFN-γ: Interferon-γ; TIMP-1: Tissue inhibitor of metalloproteinase 1.

Citation: Lee S, Heo J, Ahn EK, Kim JH, Kim YH, Chang HK, Lee SJ, Kim J, Park SJ. Conditioned secretome of adipose-derived stem cells improves dextran sulfate sodium-induced colitis in mice. World J Gastroenterol 2021; 27(23): 3342-3356
URL: https://www.wjgnet.com/1007-9327/full/v27/i23/3342.htm
DOI: https://dx.doi.org/10.3748/wjg.v27.i23.3342