Retrospective Study
Copyright ©The Author(s) 2020.
World J Gastroenterol. Feb 21, 2020; 26(7): 749-758
Published online Feb 21, 2020. doi: 10.3748/wjg.v26.i7.749
Table 1 Modified Child-Pugh scoring system
ItemScore
123
TBIL, µmol/L< 3434-51> 51
ALB, g/L> 3528-35< 28
Prothrombin time prolongation, s< 44-6> 6
PA for males, mg/L> 190130-190< 130
PA for females, mg/L> 170120-170< 120
Table 2 Baseline characteristics of the 204 patients
VariableAll patients (n = 204)
Sex (male/female)174/30
Age, yr52.0 ± 11.4
BMI, kg/m223.2 ± 3.6
Cause of hepatitis (Hepatitis B/C/Others)174/2/28
PH (yes/no)48/156
Liver cirrhosis (yes/no)120/84
P grade (A/B)187/17
BCLC stage (0 or A/B/C)113/62/29
PA, mg/L198.5 (149.3-238.0)
ALB, g/L41.0 ± 4.7
TBIL, μmol/L13.3 (9.7-18.3)
PT, s13.7 (13.0-14.5)
ALT, U/L36.0 (26.3-56.0)
AFP, μg/L76.4 (9.02-1082.5)
INR1.0 (0.98-1.1)
PLT, × 109/L135.0 (99.8-181.0)
Number of tumors (1/2/≥3)161/27/16
Tumor size, cm4.0 (3.0-6.5)
PVTT (yes/no)30/174
Capsule formation (yes/no)27/177
Differentiation (well/poor)81/123
Surgical bleeding, mL300 (180-575)
Blood transfusion (yes/no)68/136
Type of liver resection (minor/major)159/45
Intraoperative radiotherapy and/or chemotherapy (yes/no)148/56
ALBI grade (1/2/3)136/66/2
MCP grade (1/2/3)110/52/42
Overall survival time, mo44.0 (22.0-74.0)
Recurrence-free survival time, mo22.0 (5.0-45.0)
Table 3 Univariate and multivariate analyses of prognostic factors for overall survival and recurrence-free survival
VariablesOverall survival
Recurrence-free survival
Univariate
Multivariate
Univariate
Multivariate
P valueHR (95%CI)P valueP valueHR (95%CI)P value
Sex (M/F)0.5950.962
Age (> 50/< 50 yr)0.0201.853 (1.243-2.761)0.0020.071
BMI (≥ 24/<24 kg/m2)0.5960.770
Cause of hepatitis (HBV/HCV/others)0.2690.422
ALT (> 40/≤ 40 U/L)0.2550.069
AFP (≥ 400/< 400 μg/L)0.1110.092
INR (≥ 1.3/< 1.3)< 0.0010.009
PLT (≥ 100/< 100 × 109/L)0.3920.713
Number of tumors (single/≥ 2)0.2430.065
Tumor size (≥ 5/< 5 cm)< 0.001< 0.001
Blood transfusion (yes/no)0.0010.003
Surgical bleeding (> 400/≤ 400 mL)0.0050.0031.437 (1.004-2.058)0.048
Types of liver resection (minor/major)< 0.001< 0.001
Intraoperative radiotherapy and/or chemotherapy (yes/no)0.6490.430
PVTT (yes/no)< 0.0010.005
Capsule formation (yes/no)0.4080.374
Differentiation (good/poor)0.0042.230 (1.452-3.426)< 0.0010.029
PH (yes/no)0.8090.542
Liver cirrhosis (yes/no)0.9440.896
Child-Pugh grade (A/B)< 0.0010.001
BCLC stage (0 or A/B/C)< 0.001< 0.001
0 or A11
B2.635 (1.235-5.622)0.0122.246 (1.095-4.607)0.027
ALBI grade (1/2/3)< 0.0010.003
MCP grade< 0.001< 0.001
111
21.864 (1.174-2.959)0.0081.830 (1.246-2.687)0.002
32.005 (1.071-3.753)0.030