Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression

doi:10.3748/wjg.v26.i28.4140

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastroenterol. Jul 28, 2020; 26(28): 4140-4150
Published online Jul 28, 2020. doi: 10.3748/wjg.v26.i28.4140

Table 1 Analysis of correlation between insulin receptor substrate 1 expression and clinicopathologic features, n (%)

Clinicopathological features		IRS-1 expression		P Fisher exact test
Clinicopathological features		Weak (0), n = 66	Strong (1+, 2+), n = 61	P Fisher exact test
Age (yr)	≤ 60 (n = 42)	22 (33.8)	20 (33.3)	0.552
Age (yr)	> 60 (n = 83)	43 (66.2)	40 (66.7)	0.552
Gender	Male (n = 70)	37 (56.1)	33 (54.1)
Gender	Female (n = 56)	28 (42.4)	28 (45.9)
Tumor Localization	Rectum (n = 57)	33 (50.8)	24 (39.3)	0.134
Tumor Localization	Colon (n = 69)	32 (49.2)	37 (60.7)	0.134
Histological Type^a	A (n = 104)	46 (69.7)	58 (95.1)	< 0.001
Histological Type^a	MA (n = 23)	20 (30.3)	3 (4.9)	< 0.001
Histological differentiation^a	G2 (n = 87)	35 (53.8)	52 (85.2)	< 0.001
Histological differentiation^a	G3 (n = 39)	30 (46.2)	9 (14.8)	< 0.001
Tumor size	pT1 + pT2 (n = 11)	7 (10.6)	4 (6.6)	0.312
Tumor size	pT3 + pT4 (n = 116)	59 (89.4)	57 (93.4)	0.312
Lymph node Involvement	Negative (n = 60)	29 (43.9)	31 (50.8)	0.438
Lymph node Involvement	Positive (n = 67)	37 (56.1)	30 (49.2)	0.438

Correlations were analyzed by Fisher exact test.

^aP < 0.05; n: Number of cases; r: Correlation coefficient; A: Adenocarcinoma; MA: Mucinous adenocarcinoma; G2: Moderately differentiated; G3: Poorly differentiated; N (-): Negative lymph node invasion; N (+): Positive lymph node invasion.

Table 2 Analysis of correlations between Insulin receptor substrate 1, Bax and Bcl-xL expressions in primary colorectal cancer

Groups of patients			IRS-1–Bax			IRS-1–Bcl-xL
Groups of patients		n	P value	r	n	P value	r
All		123	< 0.001	0.513^a	119	< 0.001	0.354^a
Age (yr)	≤ 60	40	< 0.001	0.661^a	41	0.001	0.481^a
Age (yr)	> 60	81	< 0.001	0.424^a	76	0.020	0.267^a
Sex	Male	67	< 0.001	0.497^a	63	0.011	0.319^a
Sex	Female	55	< 0.001	0.537^a	55	0.002	0.415^a
Localization	Rectum	54	< 0.001	0.460^a	51	0.080	0.247^a
Localization	Colon	68	< 0.001	0.536^a	67	< 0.001	0.446^a
HP–type	A	101	< 0.001	0.535^a	96	< 0.001	0.535^a
HP–type	MA	22	0.953	-0.013	23	0.841	-0.044
G	G2	84	< 0.001	0.523^a	83	0.006	0.300^a
G	G3	38	0.263	0.186	35	0.474	0.125
T	pT1 + pT2	10	0.455	0.268	11	0.005	0.772^a
T	pT3 + pT4	113	< 0.001	0.529^a	108	0.001	0.302^a
N	pN (-)	58	< 0.001	0.507^a	57	0.007	0.351^a
N	pN (+)	65	< 0.001	0.493^a	62	0.007	0.336^a

Associations analyzed by Spearman's correlation rank test.

Table 3 Analysis of correlations between Insulin receptor substrate 1 and Ki-67 expression in primary colorectal cancer

Groups of patients			IRS-1 – Ki-67
Groups of patients		n	P value	r
All		102	0.589	0.054
Age (yr)	≤ 60	32	0.291	-0.193
Age (yr)	> 60	68	0.147	0.178
Sex	Male	55	0.893	0.018
Sex	Female	46	0.517	0.098
Localization	Rectum	45	0.662	-0.067
Localization	Colon	56	0.285	0.145
HP–type	A	85	0.751	0.035
HP–type	MA	17	0.239	-0.302
G	G2	71	0.845	0.024
G	G3	30	0.714	0.070
T	pT1 + pT2	8	0.043	0.723^a
T	pT3 + pT4	94	0.973	-0.004
N	pN (-)	49	0.471	0.105
N	pN (+)	53	0.999	0.000

Associations were analyzed by Spearman's correlation rank test.

Table 4 Analysis of correlations between Bax and Bcl-xL expression in primary colorectal cancer

Groups of patients			Bax–Bcl-xL
Groups of patients		n	P value	r
All		115	< 0.001	0.556^a
Age(yr)	≤ 60	39	< 0.001	0.575^a
Age(yr)	> 60	74	< 0.001	0.530^a
Sex	Male	60	< 0.001	0.453^a
Sex	Female	54	< 0.001	0.643^a
Localization	Rectum	48	< 0.001	0.490^a
Localization	Colon	66	< 0.001	0.594^a
HP–type	A	93	< 0.001	0.546^a
HP–type	MA	22	0.013	0.519^a
G	G2	80	< 0.001	0.523^a
G	G3	34	< 0.001	0.543^a
T	pT1 + pT2	10	0.537	0.222
T	pT3 + pT4	105	< 0.001	0.577^a
N	pN (-)	55	< 0.001	0.509^a
N	pN (+)	60	< 0.001	0.582^a

Associations were analyzed by Spearman's correlation rank test.

Citation: Lomperta K, Jakubowska K, Grudzinska M, Kanczuga-Koda L, Wincewicz A, Surmacz E, Sulkowski S, Koda M. Insulin receptor substrate 1 may play divergent roles in human colorectal cancer development and progression. World J Gastroenterol 2020; 26(28): 4140-4150
URL: https://www.wjgnet.com/1007-9327/full/v26/i28/4140.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i28.4140