NKX6.3 protects against gastric mucosal atrophy by downregulating β-amyloid production

Table 1 Protein expression of amyloid β oligomer, β-secretase 1, apolipoprotein E, cleaved caspase-3, and Helicobacter pylori CagA was significantly associated with gastric mucosal atrophy and inversely correlated with NKX6.3 expression

		Atrophy			NKX6.3			Aβ oligomer			Bace1			ApoE			Cleaved Casp3
		+	-	P value	+	-	P value	+	-	P value	+	-	P value	+	-	P value	+	-	P value
NKX6.3	+	3	33	0.0001
	-	15	4
Aβ oligomer	+	17	2	0.0001	3	16	0.0001
	-	1	35		33	3
Bace1	+	16	5	0.0001	2	19	0.0001	18	3	0.0001
	-	2	32		34	0		1	33
ApoE	+	18	5	0.0001	4	19	0.0001	19	4	0.0001	21	2	0.0001
	-	0	32		32	0		0	32		0	32
Cleaved Casp3	+	16	8	0.0001	5	19	0.0001	19	5	0.0001	21	3	0.0001	22	2	0.0001
	-	2	29		31	0		0	31		0	31		1	30
CagA	+	14	12	0.0041	9	17	0.0001	16	10	0.0002	19	7	0.0001	19	7	0.0001	21	5	0.0001
	-	4	25		27	2		3	26		2	27		4	25		3	26

Aβ: Amyloid β; ApoE: Apolipoprotein E; Bace1: β-secretase 1; Casp3: Caspase-3.