Influence of dietary isoflavone intake on gastrointestinal symptoms in ulcerative colitis individuals in remission

doi:10.3748/wjg.v23.i29.5356

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World Journal of Gastroenterology

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World J Gastroenterol. Aug 7, 2017; 23(29): 5356-5363
Published online Aug 7, 2017. doi: 10.3748/wjg.v23.i29.5356

Table 1 Analysis of correlation between isoflavone intakes and number of bowel movements per day declared in group of ulcerative colitis individuals (analysis conducted using Spearman rank correlation coefficient)

	P value	R
Intake
Daidzein (mg)	0.0889	-0.2509
Genistein (mg)	0.2942	0.1543
Glycitein (mg)	0.1889	0.1946
Total isoflavones (mg)	0.8987	0.0191
Intake per 1000 kcal
Daidzein (mg/1000 kcal)	0.0992	-0.2434
Genistein (mg/1000 kcal)	0.2762	0.1621
Glycitein (mg/1000 kcal)	0.1899	0.1946
Total isoflavones (mg/1000 kcal)	0.9881	-0.0022

Table 2 Isoflavone intake levels in groups of ulcerative colitis individuals declaring lack of abdominal pain and declaring presence of abdominal pain (comparison conducted using U Mann-Whitney test)

	Individuals declaring lack of abdominal pain(n = 29)		Individuals declaring abdominal pain(n = 27)		P value
	Mean ± SD	Median (min-max)	Mean ± SD	Median (min-max)	P value
Intake
Daidzein (μg)	168.3 ± 112.5	176.7 (4.3-476.7)	119.1 ± 187.2	68.0¹ (3.3-977.7)	0.0075
Genistein (μg)	177.9 ± 127.6	156.7 (5.3-444.0)	177.1 ± 287.0	125.3¹ (2.3-1428.3)	0.1356
Glycitein (μg)	0.5 ± 2.6	0.0¹ (0.0-14.0)	3.4 ± 12.3	0.0¹ (0.0-56.0)	0.2706
Total isoflavones (μg)	346.6 ± 185.2	333.3 (7.7-770.7)	299.6 ± 362.2	177.3¹ (18.0-1574.0)	0.0358
Intake per 1000 kcal
Daidzein (μg/1000 kcal)	94.6 ± 86.1	69.9¹ (1.3-347.7)	60.4 ± 79.1	46.2¹ (2.1-392.7)	0.0358
Genistein (μg/1000 kcal)	88.3 ± 69.6	86.2¹ (1.6-279.5)	100.4 ± 161.4	57.4¹ (1.4-759.2)	0.2378
Glycitein (μg/1000 kcal)	0.3 ± 1.5	0.0¹ (0.0-8.0)	2.1 ± 7.8	0.0¹ (0.0-37.4)	0.2706
Total isoflavones (μg/1000 kcal)	183.1 ± 130.9	137.2 (8.3-517.2)	162.9 ± 193.5	119.7¹ (8.6-836.7)	0.1400

¹Nonparametric distribution (verified using the Shapiro-Wilk test; P < 0.05).

Table 3 Isoflavone intake levels in groups of ulcerative colitis individuals declaring lack of flatulence and declaring presence of flatulence (comparison conducted using U Mann-Whitney test)

	Individuals declaring lack of flatulence (n = 46)		Individuals declaring flatulence (n = 10)		P value
	Mean ± SD	Median (min-max)	Mean ± SD	Median (min-max)	P value
Intake
Daidzein (μg)	147.4 ± 165.6	115.0¹ (3.3-977.7)	131.4 ± 843	109.8 (19.0-278.0)	0.7727
Genistein (μg)	187.6 ± 225.4	140.0¹ (2.3-1428.3)	131.1 ± 177.6	78.3¹ (7.3-586.7)	0.2186
Glycitein (μg)	2.2 ± 9.7	0.0¹ (0.0-56.0)	0.4 ± 1.3	0.0¹ (0.0-4.0)	0.7738
Total isoflavones (μg)	337.2 ± 293.4	302.5¹ (18.0-1574.0)	262.9 ± 232.2	220.8¹ (37.3-833.0)	0.4162
Intake per 1000 kcal
Daidzein (μg/1000 kcal)	78.9 ± 89.1	53.9¹ (1.3-392.7)	74.3 ± 56.6	60.8 (12.1-56.6)	0.6455
Genistein (μg/1000 kcal)	97.3 ± 121.5	68.1¹ (1.4-759.2)	79.4 ± 128.7	32.3¹ (3.6-426.6)	0.2268
Glycitein (μg/1000 kcal)	1.4 ± 6.1	0.0¹ (0.0-37.4)	0.3 ± 0.9	0.0¹ (0.0-2.9)	0.7738
Total isoflavones (μg /1000 kcal)	177.6 ± 162.9	133.5¹ (8.3-836.7)	154.0 ± 170.0	133.9¹ (21.7-605.7)	0.5854

¹Nonparametric distribution (verified using the Shapiro-Wilk test; P < 0.05).

Table 4 Isoflavone intake levels in groups of ulcerative colitis individuals declaring lack of constipations and declaring presence of constipations (comparison conducted using U Mann-Whitney test)

	Individuals declaring lack of constipations(n = 49)		Individuals declaring constipations(n = 7)		P value
	Mean ± SD	Median (min-max)	Mean ± SD	Median (min-max)	P value
Intake
Daidzein (μg)	147.0 ± 158.0	117.7¹ (3.3-977.7)	127.0 ± 128.6	73.0 (11.3-353.0)	0.6827
Genistein (μg)	183.6 ± 219.9	137.0¹ (2.3-1428.3)	134.9 ± 208.8	67.0¹ (6.7-586.7)	0.1891
Glycitein (μg)	1.0 ± 5.1	0.0¹ (0.0-33.3)	8.6 ± 21.0	0.0¹ (0.0-56.0)	0.0213
Total isoflavones (μg)	331.6 ± 282.8	262.7¹ (27.7-1574.0)	270.5 ± 300.4	123.7 (18.0-833.0)	0.3339
Intake per 1000 kcal
Daidzein (μg/1000 kcal)	146.8 ± 161.0	117.7¹ (3.3-977.7)	101.1 ± 124.2	46.2 (5.4-347.7)	0.9802
Genistein (μg/1000 kcal)	183.3 ± 224.2	137.0¹ (2.3-1428.3)	97.6 ± 152.0	37.1¹ (3.2-426.6)	0.4279
Glycitein (μg/1000 kcal)	1.0 ± 5.2	0.0¹ (0.0-33.3)	5.7 ± 6.7	0.0¹ (0.0-37.4)	0.0213
Total isoflavones (μg/1000 kcal)	331.1 ± 287.9	262.7¹ (27.7-1574.0)	204.5 ± 236.1	68.4 (8.6-605.7)	0.7102

¹Nonparametric distribution (verified using the Shapiro-Wilk test; P < 0.05).

Table 5 Isoflavone intake levels in groups of ulcerative colitis individuals declaring lack of tenesmus and declaring presence of tenesmus (comparison conducted using U Mann-Whitney test)

	Individuals declaring lack of constipations(n = 47)		Individuals declaring constipations(n = 9)		P value
	Mean ± SD	Median (min-max)	Mean ± SD	Median (min-max)	P value
Intake
Daidzein (μg)	124.5 ± 107.8	101.0¹ (3.3-476.7)	249.4 ± 284.4	205.7¹ (5.3-977.7)	0.0818
Genistein (μg)	190.4 ± 233.0	138.0¹ (2.3-1428.3)	110.0 ± 79.7	126.0 (7.3-253.7)	0.3662
Glycitein (μg)	2.3 ± 9.6	0.0¹ (0.0-56.0)	0.0 ± 0.0	0.0¹ (0.0-0.0)	0.3819
Total isoflavones (μg)	317.2 ± 280.2	302.3¹ (18.0-1574.0)	359.4 ± 311.7	242.3¹ (139.3-1137.7)	0.7379
Intake per 1000 kcal
Daidzein (μg/1000 kcal)	70.6 ± 76.7	48.1¹ (1.3-347.7)	117.2 ± 111.6	95.1¹ (4.5-392.7)	0.0943
Genistein (μg/1000 kcal)	101.4 ± 130.7	69.1¹ (1.4-759.2)	55.7 ± 42.5	46.5 (3.6-117.4)	0.3722
Glycitein (μg/1000 kcal)	1.4 ± 6.1	0.0¹ (0.0-37.4)	0.0 ± 0.0	0.0¹ (0.0-0.0)	0.3819
Total isoflavones (μg/1000 kcal)	173.4 ± 171.7	131.2¹ (8.3-836.7)	173.0 ± 113.5	140.9¹ (73.4-456.9)	0.5770

¹Nonparametric distribution (verified using the Shapiro-Wilk test; P < 0.05).

Citation: Głąbska D, Guzek D, Grudzińska D, Lech G. Influence of dietary isoflavone intake on gastrointestinal symptoms in ulcerative colitis individuals in remission. World J Gastroenterol 2017; 23(29): 5356-5363
URL: https://www.wjgnet.com/1007-9327/full/v23/i29/5356.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i29.5356