Copyright
©The Author(s) 2017.
World J Gastroenterol. Apr 14, 2017; 23(14): 2613-2624
Published online Apr 14, 2017. doi: 10.3748/wjg.v23.i14.2613
Published online Apr 14, 2017. doi: 10.3748/wjg.v23.i14.2613
Table 1 General characteristics and basic laboratory tests of cirrhotic patients with and without portal vein thrombosis
| All patients | PVT (+) | PVT (-) | P value | |
| n = 51 | n = 17 | n = 34 | ||
| Sex (M/F), n (%) | 35/16 (68.6/31.4) | 12/5 (70.6/29.4) | 23/11 (67.6/32.4) | P > 0.05 |
| Age (yr) | 52 (26-80) | 56 (26-80) | 54 (27-68) | P > 0.05 |
| BMI (kg/m2) | 27 (17-40) | 27 (20-40) | 27 (17-36) | P > 0.05 |
| Child-Pugh (points) | 7.7 (5-12) | 7.3 (5-11) | 7.9 (5-12) | P > 0.05 |
| MELD score (points) | 13.9 (6-26) | 12.8 (9-22) | 14.5 (6-26) | P > 0.05 |
| Bilirubin (mg/dL) | 3.4 (0.6-14.3) | 2.3 (1.1-4.8) | 3.9 (0.6-14.3) | P > 0.05 |
| Hemoglobin (g/dL) | 7.5-15.3 | 11.9 (8.4-15) | 12.2 (7.5-15.3) | P > 0.05 |
| Platelets (× 103/mm3) | 96 (18-330) | 83 (32-149) | 103 (18-330) | P > 0.05 |
| WBC (× 103/mm3) | 5.1 (1.3-15.3) | 4.3 (1.9-11.2) | 5.5 (1.3-15.3) | P > 0.05 |
| Albumin (g/dL) | 3.2 (1.7-5.1) | 3.2 (2.4-4.3) | 3.2 (1.7-5.1) | P > 0.05 |
| ALT (U/L) | 39 (15-130) | 41.6 (15-130) | 38.1 (15-115) | P > 0.05 |
| AST (U/L) | 71.2 (18-216) | 69 (18-164) | 72.1 (20-216) | P > 0.05 |
| GGTP (U/L) | 122 (25-489) | 180.3 (25-489)1 | 91.2 (13-236) | P = 0.02 |
| Cholesterol (mg/dL) | 176 (45-409) | 147.8 (45-284) | 187 (87-409) | P > 0.05 |
| HDL-Ch (mg/dL) | 46.2 (13-78) | 33.6 (17-45) | 49.6 (13-78) | P > 0.05 |
| LDL-Ch (mg/dL) | 97.5 (19-203) | 83 (19-171) | 102.4 (43-203) | P > 0.05 |
| TG (mg/dL) | 127 (47-407) | 133.3 (47-341) | 125.3 (48-407) | P > 0.05 |
| Ascites | 19/51 (42%) | 8/17 (47%) | 15/34 (44%) | P > 0.05 |
Table 2 Coagulation parameters and platelet activity tests in cirrhotic patients with and without portal vein thrombosis
| PVT (+) | PVT (-) | P value | |
| n = 17 | n = 34 | ||
| PT (s) | 15.5 (12.5-21.9) | 16.8 (11.3-44) | P > 0.05 |
| Prothrombin activity (%) | 67.8 (41-92) | 66.5 (36-106) | P > 0.05 |
| INR | 1.37 (1.11-1.9) | 1.36 (1-2.19) | P > 0.05 |
| APTT | 35.5 (29.1-57) | 34.4 (23.6-49.4) | P > 0.05 |
| TRAP test | 37.2 (12-113) | 55.6 (16-156) | P = 0.03 |
| ASPI test | 29.1 (5-108) | 40.5 (5-130) | P > 0.05 |
| ADP test | 25.8 (1-94) | 34.5 (5-99.9) | P > 0.05 |
| RISTO low test | 9.5 (1-35) | 11.6 (0-33) | P > 0.05 |
| RISTO high test | 46.4 (5-162) | 61.5 (4-156) | P > 0.05 |
| D-dimer (mg/L) | 4434 (663-9455) | 3134 (563-11026) | P > 0.05 |
| Protein C (%) | 56.9 (38.1-90.3) | 65.1 (20.9-177.5) | P > 0.05 |
| Prothrombin (µg/mL) | 175.6 (71-390) | 117.4 (36-422) | P = 0.01 |
| von Willebrand factor (mU/mL) | 1872 (1328-2339) | 1906 (981-2372) | P > 0.05 |
| von Willebrand factor activity (IU/mL) | 3.75 (1.72-6.61) | 4.01 (1.01-7.71) | P > 0.05 |
Table 3 Adipokine serum levels, insulin resistance profile and diabetes occurrence in cirrhotic patients with and without portal vein thrombosis
| PVT (+) | PVT (-) | P value | |
| n = 17 | n = 34 | ||
| Diabetes, n (%) | 5/17 (29%) | 10/34 (29%) | P > 0.05 |
| Glucose (mg/dL) | 128.4 (86-309) | 122.8 (82-430) | P > 0.05 |
| (N:75-115 mg/dL) | |||
| Insulin (μIU/mL) | 19.5 (8.7-41.7) | 17.8 (6.1-47.6) | P > 0.05 |
| HOMA-IR | 6.6 (2.5-14.1) | 5.3 (0.9-13.4) | P > 0.05 |
| Omentin (ng/mL) | 855 (579-1205) | 1105 (619-2208) | P = 0.01 |
| Vaspin (ng/mL) | 0.31 (0.09-0.84) | 0.27 (0.09-0.78) | P > 0.05 |
Table 4 Coagulation factors and platelet activity test results with regards to the severity of cirrhosis, as assessed according to the Child-Pugh score
| All patients (n = 51) | Child-Pugh A | Child-Pugh B | Child-Pugh C | |
| (n = 16) | (n = 25) | (n = 10) | ||
| Thrombosis | 17/51 (33%) | 6/16 (37.5%) | 9/25 (24%) | 2/10 (20%) |
| PT (s) | 13.8 (11.3-44) | 13.8 (11.3-16.9) | 16.7 (11.3-44)13 | 19.2 (14.1-24.4)12 |
| Prothrombin activity (%) | 67 (36-106) | 79.2 (58-106) | 65.4 (43-95)13 | 51.4 (36-73)12 |
| INR | 1.3 (1-2.2) | 1.2 (1-1.5) | 1.4 (1.1-2)13 | 1.7 (1.2-2.2)12 |
| APTT | 34.7 (23.6-57) | 32.3 (23.6-47.4) | 36.2 (29.1-57)1 | 35.6 (28.2-44) |
| TRAP test | 49.6 (12-156) | 54.5 (15-156) | 43.5 (12-98) | 53.3 (16-113) |
| ASPI test | 36.8 (5-130) | 45.6 (10-130) | 32.3 (5-110) | 34.2 (5-108) |
| ADP test | 31.6 (1-99.9) | 36.3 (13-99.9) | 25.8 (1-77) | 38.4 (9-94) |
| RISTO low test | 10.9 (0-35) | 10.5 (1-25) | 8.9 (0-26) | 16.4 (2-35) |
| RISTO high test | 56.5 (4-162) | 65.5 (7-152) | 41 (4-156) | 60.49 (17-162) |
| D-dimer (mg/L) | 3568 (563-11026) | 2521 (563-9455) | 3243 (795-8790)3 | 6053 (724-11026)12 |
| Protein C (%) | 56.5 (20.9-177.5) | 60.9 (49.1-105.1) | 60.8 (20.9-177.5) | 58.3 (29.4-121.1) |
| Prothrombin (μg/mL) | 136.8 (36-422) | 128.9 (43.1-390) | 152.1 (36-422) | 110.2 (60.4-194) |
| vWf (mU/mL) | 1941 (981-2372) | 1789 (986-2372) | 1941 (981-2339) | 2062 (1450-2311)1 |
| vWf activity (IU/mL) | 3.8 (1-7.7) | 3.3 (1.5-7.6) | 3.8 (1-7.7) | 4.8 (2.6-6.6)1 |
| Omentin (ng/mL) | 1023 (579-2208) | 942 (635-1432) | 964 (579-2208) | 1102 (657-1571) |
| Vaspin (ng/mL) | 0.29 (0.1-0.8) | 0.2 (0.1-0.6) | 0.3 (0.1-0.8) | 0.4 (0.1-0.7) |
Table 5 Coagulation factors and platelet activity test with regards to the severity of cirrhosis, as evaluated according to the model of end-stage liver disease score
| All patients (n = 51) | MELD ≤ 18 (n = 28) | MELD > 18 (n = 23) | |
| Thrombosis | 17/51 (33%) | 11/28 (39.2%) | 7/23 (30.4%) |
| PT (s) | 13.8 (11.3-44) | 14.1 (11.3-21) | 19.1 (13.4.-44)1 |
| Prothrombin activity (%) | 67 (36-106) | 76.4 (43-106) | 55.6 (36-86)1 |
| INR | 1.3 (1-2.2) | 1.3 (1-1.5) | 1.6 (1.2-2.2)1 |
| APTT | 34.7 (23.6-57) | 35.1 (23.6-57) | 34.4 (28.2-44.9) |
| TRAP test | 49.6 (12-156) | 56.2 (15-156) | 42.1 (12-113)1 |
| ASPI test | 36.8 (5-130) | 45.9 (10-130) | 26.4 (5-108)1 |
| ADP test | 31.6 (1-99.9) | 36.2 (7-99.9) | 26.5 (1-94) |
| RISTO low test | 10.9 (0-35) | 10.6 (1-25) | 11.3 (0-35) |
| RISTO high test | 56.5 (4-162) | 68.5 (7-156) | 43 (4-162)1 |
| D-dimer (mg/L) | 3568 (563-11026) | 3094 (563-9455) | 4144 (724-11026) |
| Protein C (%) | 56.5 (20.9-177.5) | 58.7 (20.9-105.1) | 66.7 (29.4-177.5) |
| Prothrombin (μg/mL) | 136.8 (36-422) | 143.6 (36-390) | 128.5 (59-422) |
| vWf (mU/mL) | 1941 (981-2372) | 1841 (986-2372) | 2006 (981-2311)1 |
| vWf (IU/mL) | 3.8 (1-7.7) | 3.7 (1.5-7.6) | 4.2 (1-7.7) |
| Omentin (ng/mL) | 1023 (579-2208) | 948 (579-1432) | 1110 (619-2208) |
| Vaspin (ng/mL) | 0.29 (0.1-0.8) | 0.25 (0.1-0.8) | 0.32 (0.1-0.8) |
Table 6 Coagulation factors, platelet activity tests and adipokines levels with regards to the presence of chronic hepatitis C
| All patients (n = 51) | HCV (+) (n = 15) | HCV (-) (n = 36) | |
| Thrombosis | 17/51 (33%) | 3/11 (27.3%) | 14/40 (35%) |
| PT (s) | 13.8 (11.3-44) | 14.5 (11.3-19.9) | 16.8 (11.3-44) |
| Prothrombin activity (%) | 67 (36-106) | 72.1 (47-94) | 65.6 (36-106) |
| INR | 1.3 (1-2.2) | 1.3 (1-1.8) | 1.4 (1.2-2.2) |
| APTT | 34.7 (23.6-57) | 36.6 (28.2-57) | 34.8 (23.6-49.4) |
| TRAP test | 49.6 (12-156) | 53.3 (15-156) | 47.5 (12-113) |
| ASPI test | 36.8 (5-130) | 37.9 (10-130) | 36.5 (5-110) |
| ADP test | 31.6 (1-99.9) | 33.4 (13-99.9) | 31.2 (1-94) |
| RISTO low test | 10.9 (0-35) | 13.5 (4-25) | 10.2 (0-35) |
| RISTO high test | 56.5 (4-162) | 44.5 (7-115) | 60.1 (4-162) |
| D-dimer (mg/L) | 3568 (563-11026) | 3317 (595-10043) | 3637 (563-11026) |
| Protein C (%) | 56.5 (20.9-177.5) | 65.1 (41.4-105.1) | 61.6 (20.9-177.5) |
| Prothrombin (μg/mL) | 136.8 (36-422) | 149.2 (59.7-390) | 133.4 (36-422) |
| vWf (mU/mL) | 1941 (981-2372) | 1912 (986-2311) | 1890 (981-2372) |
| vWf activity (IU/mL) | 3.8 (1-7.7) | 4.2 (1.5-6.4) | 3.9 (1-7.7) |
| Omentin (ng/mL) | 1023 (579-2208) | 991 (731-1432) | 1028 (579-2208) |
| Vaspin (ng/mL) | 0.29 (0.1-0.84) | 0.43 (0.1-0.77) | 0.26 (0.1-0.84) |
Table 7 Coagulation factors, platelet activity tests and adipokines levels with regards to the etiology of alcoholic liver cirrhosis
| All patients (n = 51) | Alcoholic cirrhosis (n = 30) | Non-alcoholic cirrhosis (n = 21) | |
| Thrombosis | 17/51 (33%) | 9/30 (30%) | 8/21 (38%) |
| PT (s) | 13.8 (11.3-44) | 17 (11.3-44) | 15.3 (11.3-21) |
| Prothrombin activity (%) | 67 (36-106) | 65.7 (36-106) | 68.8 (43-94) |
| INR | 1.3 (1-2.2) | 1.5 (1-2.2) | 1.4 (1.1-2) |
| APTT | 34.7 (23.6-57) | 34.6 (23.6-47.4) | 34.8 (28.2-57) |
| TRAP test | 49.6 (12-156) | 51.2 (16-113) | 47.2 (12-156) |
| ASPI test | 36.8 (5-130) | 39.1 (5-110) | 33.4 (5-130) |
| ADP test | 31.6 (1-99.9) | 32.8 (5-94) | 29.9 (1-99.9) |
| RISTO low test | 10.9 (0-35) | 11.4 (0-35) | 10.15 (1-25) |
| RISTO high test | 56.5 (4-162) | 68.4 (10-162) | 39.5 (4-115) |
| D-dimer (mg/L) | 3568 (563-11026) | 3635 (563-11026) | 3471 (595-10043) |
| Protein C (%) | 56.5 (20.9-177.5) | 59.2 (20.9-121.2) | 66.8 (33.4-177.5) |
| Prothrombin (μg/mL) | 136.8 (36-422) | 116.6 (36-382) | 165.8 (59-422)1 |
| vWf (mU/mL) | 1941 (981-2372) | 1937 (1209-2372) | 1834 (981-2311) |
| vWf (IU/mL) | 3.8 (1-7.7) | 4.1 (1.5-7.7) | 3.7 (1-6.4) |
| Omentin (ng/mL) | 1023 (579-2208) | 1072 (579-2208) | 923 (635-1432) |
| Vaspin (ng/mL) | 0.29 (0.1-0.84) | 0.29 (0.1-0.84) | 0.26 (0.1-0.72) |
- Citation: Kukla M, Waluga M, Żorniak M, Berdowska A, Wosiewicz P, Sawczyn T, Bułdak RJ, Ochman M, Ziora K, Krzemiński T, Hartleb M. Serum omentin and vaspin levels in cirrhotic patients with and without portal vein thrombosis. World J Gastroenterol 2017; 23(14): 2613-2624
- URL: https://www.wjgnet.com/1007-9327/full/v23/i14/2613.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i14.2613